HS1371

Product Name: HS1371
CAS No.: 2158197-70-5
Chemical Name: HS1371
Synonyms: HS1371;CS-2831;HS-1371; HS 1371; HS1371;2158197-70-5;7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline;Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;HS-1371,Inhibitor,Receptor-interacting protein kinases,RIPK,inhibit,HS 1371,RIP kinase,HS1371
CBNumber: CB14800382
Molecular Formula: C24H24N4O
Formula Weight: 384.47
MOL File: 2158197-70-5.mol

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HS1371 Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMF:30.0(Max Conc. mg/mL);78.03(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.52(Max Conc. mM)
DMSO:11.56(Max Conc. mg/mL);30.06(Max Conc. mM)
Ethanol:4.5(Max Conc. mg/mL);11.7(Max Conc. mM)
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573183
Product name: HS-1371
Purity: >98%
Packaging: 100mg
Price: $1060.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573183
Product name: HS-1371
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573183
Product name: HS-1371
Purity: >98%
Packaging: 1g
Price: $3580.2
Updated: 2021/12/16

Ambeed

Product number: A982329
Product name: HS1371
Purity: 97%
Packaging: 5mg
Price: $106
Updated: 2021/12/16

Ambeed

Product number: A982329
Product name: HS1371
Purity: 97%
Packaging: 10mg
Price: $169
Updated: 2021/12/16

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HS1371 Chemical Properties,Usage,Production

Biological Activity

HS1371 is a potent RIP3 kinase inhibitor with IC50 of 20.8 nM. It binds to the ATP-binding region of RIP3, thereby preventing ATP binding, inhibiting the enzymatic activity of RIP3 in vitro.

in vitro

HS1371 inhibits autorenal phosphorylation of RIP3 at S227. In HT-29 cells, it has full inhibitory activity on TNF-induced necroptosis signaling and is inactive on the phosphorylation of RIP3 and MLKL. It protects cells from RIP3-dependent necrotic cell death but does not affect apoptotic cell death.

target

Target	Value
RIP3 kinase ()	20.8 nM

HS1371 Preparation Products And Raw materials

Raw materials

Preparation Products

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HS1371 Suppliers

China 48 India 1 United States 7 Global 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1009
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4601
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7267
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1847
Advantage: 55

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: +86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 894
Advantage: 55

2158197-70-5, HS1371Related Search:

HS1371

CS-2831

HS-1371; HS 1371; HS1371;2158197-70-5

Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

HS-1371,Inhibitor,Receptor-interacting protein kinases,RIPK,inhibit,HS 1371,RIP kinase,HS1371

7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline

2158197-70-5

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