AM 92016 hydrochloride

Product Name: AM 92016 hydrochloride
CAS No.: 133229-11-5
Chemical Name: AM 92016 hydrochloride
Synonyms: AM92016,Inhibitor,inhibit,AM 92016,AM 92016 hydrochloride,AM92016 hydrochloride,AM-92016;N-[4-[3-[[2-(3,4-Dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]methanesulfonamide hydrochloride
CBNumber: CB14806425
Molecular Formula: C19H25Cl3N2O4S
Formula Weight: 483.83
MOL File: 133229-11-5.mol

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AM 92016 hydrochloride Property

storage temp.: 4°C, protect from light
solubility: <48.38mg/ml in DMSO; <24.19mg/ml in H2O
form: solid
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A634675
Product name: AM92016Hydrochloride
Packaging: 1mg
Price: $105
Updated: 2021/12/16

ApexBio Technology

Product number: B6482
Product name: AM92016hydrochloride
Packaging: 5mg
Price: $158
Updated: 2021/12/16

ApexBio Technology

Product number: B6482
Product name: AM92016hydrochloride
Packaging: 10mg
Price: $284
Updated: 2021/12/16

ApexBio Technology

Product number: B6482
Product name: AM92016hydrochloride
Packaging: 50mg
Price: $929
Updated: 2021/12/16

DC Chemicals

Product number: DC26176
Product name: AM92016
Packaging: 100mg
Price: $600
Updated: 2021/12/16

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AM 92016 hydrochloride Chemical Properties,Usage,Production

Biological Activity

am 92016 hydrochloride is a specific inhibitor of delayed rectifier potassium current [1].potassium channel is an ion channel and acts to reset the resting potential and shapes the action potential. delayed rectifier potassium channel (ik) is activated by the influx of na+ and discharges k+, which repolarizes the membrane. ik restricts the duration of the nerve impulse.am 92016 hydrochloride is a specific ik inhibitor. in guinea-pig and rabbit ventricular cells, am 92016 significantly increased action potential duration with 20% and 90% repolarization levels, respectively. also, am 92016 (1 μm) inhibited ik activated by step depolarizations in a time-dependent way [1]. in rabbit sino-atrial node cells, am 92016 (50 nm) significantly inhibited ik with ic50 value of 40 nm in a concentration-dependent way [2]. in vascular smooth muscle cells (vsmc), am92016 hydrochloride inhibited no-induced erk1/2 dephosphorylation [3].in guinea-pigs, am 92016 (1-5 mg/kg) significantly increased heart rate, left ventricular systolic pressure, systolic arterial blood pressure and the contractile index dp dtmax. am 92016 exhibited proarrhythmic activity [4].

References

[1]. connors sp, gill ew, terrar da. actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. br j pharmacol, 1992, 106(4): 958-965.
[2]. lei m, brown hf. inhibition by compound ii, a sotalol analogue, of delayed rectifier current (ik) in rabbit isolated sino-atrial node cells. naunyn schmiedebergs arch pharmacol, 1998, 357(3): 260-267.
[3]. palen di, belmadani s, lucchesi pa, et al. role of shp-1, kv.1.2, and cgmp in nitric oxide-induced erk1/2 map kinase dephosphorylation in rat vascular smooth muscle cells. cardiovasc res, 2005, 68(2): 268-277.
[4]. hagerty mj, wainwright cl, kane ka. the in-vivo cardiovascular effects of a putative class iii anti-arrhythmic drug, am 92016. j pharm pharmacol, 1996, 48(4): 417-421.

AM 92016 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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AM 92016 hydrochloride Suppliers

China 26 United States 7 USA 1 Global 34

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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InvivoChem

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DC Chemicals

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Wuxi Donghe Pharmaceutical Technology Co., Ltd.

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Shanghai Kaiwei Chemical Technology Co., Ltd.

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133229-11-5, AM 92016 hydrochlorideRelated Search:

N-[4-[3-[[2-(3,4-Dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]methanesulfonamide hydrochloride

AM92016,Inhibitor,inhibit,AM 92016,AM 92016 hydrochloride,AM92016 hydrochloride,AM-92016

133229-11-5