3BETA-HYDROXY-DELTA5-CHOLENIC ACID
- Product Name
- 3BETA-HYDROXY-DELTA5-CHOLENIC ACID
- CAS No.
- 5255-17-4
- Chemical Name
- 3BETA-HYDROXY-DELTA5-CHOLENIC ACID
- Synonyms
- ZK-115757;CHOLENIC ACID;3β-Hydroxy-Δ5<;5-Cholenic Acid-32-ol;5-cholenic acid-3B-ol;5-cholenic acid-3β-ol;Carpropamid Impurity 9;3β-Hydroxycholenic Acid;5-CHOLENIC ACID-3BETA-OL;5-Cholenic Acid-3β-Hydroxy
- CBNumber
- CB1481084
- Molecular Formula
- C24H38O3
- Formula Weight
- 374.57
- MOL File
- 5255-17-4.mol
3BETA-HYDROXY-DELTA5-CHOLENIC ACID Property
- Melting point:
- 232°C
- Boiling point:
- 522.8±23.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- refractive index
- -39.5 ° (C=1, Dioxane)
- storage temp.
- Refrigerator
- solubility
- Dioxane (Slightly, Sonicated), DMF (Slightly), DMSO (Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 4.76±0.10(Predicted)
- color
- White to Pale Yellow
- InChIKey
- HIAJCGFYHIANNA-ZSWKZNPUNA-N
- SMILES
- C[C@]12CC[C@]3([H])[C@]4(CC[C@H](O)CC4=CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)O)C |&1:1,4,6,9,15,17,21,23,r|
- CAS DataBase Reference
- 5255-17-4
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 29543
- Product name
- Cholenic Acid
- Packaging
- 100mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 29543
- Product name
- Cholenic Acid
- Packaging
- 1g
- Price
- $721
- Updated
- 2024/03/01
- Product number
- 29543
- Product name
- Cholenic Acid
- Packaging
- 250mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 29543
- Product name
- Cholenic Acid
- Packaging
- 500mg
- Price
- $433
- Updated
- 2024/03/01
- Product number
- C431010
- Product name
- 5-Cholenic acid-3β-ol
- Packaging
- 250mg
- Price
- $375
- Updated
- 2021/12/16
3BETA-HYDROXY-DELTA5-CHOLENIC ACID Chemical Properties,Usage,Production
Description
Cholenic acid is a monohydroxy bile acid. It is a cholesterol oxidation product formed by 7α-hydroxylation of 27-hydroxycholesterol (Item Nos. 14790 | 14791), as well as a precursor in the biosynthesis of chenodeoxycholic acid . Levels of cholenic acid are increased in patients with neonatal liver disease harboring mutations in CYP7A1, the gene encoding 7α-hydroxylase, as well as in patients with intrahepatic and extrahepatic cholestasis.
Uses
5-Cholenic Acid-3β-ol is a bile acid of which the metabolism in humans results in the primary bile acids lithocholic acid and chenodeoxycholic. It is found in hgher concentrations in meconium of premature human babies when compared to full term babies.
Definition
ChEBI: 3b-Hydroxy-5-cholenoic acid is a steroid.
IC 50
Human Endogenous Metabolite
References
[1] C LEE N B J K O Martin. Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway.[J]. Journal of Lipid Research, 1996, 37 6: 1356-1362.
[2] K D SETCHELL. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease.[J]. Journal of Clinical Investigation, 1998, 102 9: 1690-1703. DOI: 10.1172/jci2962
[3] K SUGIYAMA. Clinical evaluation of serum 3 beta-hydroxy-5-cholenoic acid in hepatobiliary diseases.[J]. Gastroenterologia Japonica, 1986, 21 6: 608-616. DOI: 10.1007/bf02774489
3BETA-HYDROXY-DELTA5-CHOLENIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3BETA-HYDROXY-DELTA5-CHOLENIC ACID Suppliers
- Tel
- --
- Fax
- --
- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82