(S)-PBMC (PBMC) Property

Boiling point:

584.6±50.0 °C(Predicted)

Density 

1.165±0.06 g/cm3(Predicted)

storage temp. 

-20°C (des.)

solubility 

Soluble in DMSO (up to 30 mg/ml).

pka

9.17±0.10(Predicted)

form 

oil

color 

Light brown

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Hazard and Precautionary Statements (GHS)

(S)-PBMC (PBMC) Chemical Properties,Usage,Production

Description

PBMC (1352138-54-5) is a potent and selective blocker of TRPM8 channels. PBMC blocks both chemical and thermal activation of TRPM8.1?Reverses the menthol and cold-induced facilitation of the micturition reflex.2?PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3

References

1) Knowlton et al. (2011), Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice; PLoS One, 6(9) e25894 2) Gardiner et al. (2014), The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist; Eur. J. Pharmacol., 740 398 3) Salat et al. (2013), Transient receptor potential channels – emerging novel drug targets for the treatment of pain; Curr. Med. Chem., 20 1409