A-381393
- Product Name
- A-381393
- CAS No.
- 726174-00-1
- Chemical Name
- A-381393
- Synonyms
- A-381393;A-381393, 10 mM in DMSO;A-381393;A 381393;A381393;inhibit,Dopamine Receptor,A381393,Inhibitor,A-381393,A 381393;1H-Benzimidazole, 2-[[4-(3,4-dimethylphenyl)-1-piperazinyl]methyl]-;2-{[4-(3,4-dimethylphenyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole;2-((4-(3,4-Dimethylphenyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole
- CBNumber
- CB14844423
- Molecular Formula
- C20H24N4
- Formula Weight
- 320.43
- MOL File
- 726174-00-1.mol
A-381393 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:51.67(Max Conc. mg/mL);161.25(Max Conc. mM)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CS-0066859
- Product name
- A-381393
- Purity
- 99.96%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0066859
- Product name
- A-381393
- Purity
- 99.96%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0066859
- Product name
- A-381393
- Purity
- 99.96%
- Packaging
- 25mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CS-0066859
- Product name
- A-381393
- Purity
- 99.96%
- Packaging
- 50mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- orb573240
- Product name
- A-381393
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
A-381393 Chemical Properties,Usage,Production
Uses
A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1].
IC 50
D3 Receptor; D4 Receptor
References
[1] Nakane M, et al. 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21. DOI:10.1016/j.neuropharm.2005.02.004
A-381393 Preparation Products And Raw materials
Raw materials
Preparation Products
A-381393 Suppliers
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