ACT-389949 (ACT389949)

Product Name: ACT-389949 (ACT389949)
CAS No.: 1258417-54-7
Chemical Name: ACT-389949 (ACT389949)
Synonyms: ACT-389949 (ACT389949);5-Pyridinebutanoicacid,α,γ-dioxo-,methylester;inhibit,ACT389949,Inhibitor,ACT 389949,ACT-389949;N-(2-((4-(1,1-Difluoroethyl)oxazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-2-methyl-5-(m-tolyl)oxazole-4-carboxamide;N-2-4-(1,1-Difluoro-ethyl)-2-oxazolylmethyl-2H-1,2,3-triazol-4-yl-2-methyl-5-(3-methylphenyl)-4-oxazolecarboxamide;2-methyl-5-m-tolyloxazol-4-carboxylic acid {2-[4-(1,1-difluoroethyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl}amide;N-[2-[[4-(1,1-difluoroethyl)-1,3-oxazol-2-yl]methyl]triazol-4-yl]-2-methyl-5-(3-methylphenyl)-1,3-oxazole-4-carboxamide;4-Oxazolecarboxamide, N-[2-[[4-(1,1-difluoroethyl)-2-oxazolyl]methyl]-2H-1,2,3-triazol-4-yl]-2-methyl-5-(3-methylphenyl)-
CBNumber: CB14844438
Molecular Formula: C20H18F2N6O3
Formula Weight: 428.39
MOL File: 1258417-54-7.mol

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ACT-389949 (ACT389949) Property

form: Solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC20639
Product name: ACT-389949
Purity: >98%
Packaging: 50mg
Price: $1600
Updated: 2021/12/16

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ACT-389949 (ACT389949) Chemical Properties,Usage,Production

Uses

ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].

in vivo

ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours^[1].
Administration of ACT-389949 results in a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes^[1].

References

[1] Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486. DOI:10.1111/bcp.13149
[2] Lind S, et al. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019 Aug;166:163-173. DOI:10.1016/j.bcp.2019.04.030

ACT-389949 (ACT389949) Preparation Products And Raw materials

Raw materials

Preparation Products

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ACT-389949 (ACT389949) Suppliers

China 33 United States 5 Global 38

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1258417-54-7, ACT-389949 (ACT389949)Related Search:

ACT-389949 (ACT389949)

2-methyl-5-m-tolyloxazol-4-carboxylic acid {2-[4-(1,1-difluoroethyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl}amide

4-Oxazolecarboxamide, N-[2-[[4-(1,1-difluoroethyl)-2-oxazolyl]methyl]-2H-1,2,3-triazol-4-yl]-2-methyl-5-(3-methylphenyl)-

N-[2-[[4-(1,1-difluoroethyl)-1,3-oxazol-2-yl]methyl]triazol-4-yl]-2-methyl-5-(3-methylphenyl)-1,3-oxazole-4-carboxamide

5-Pyridinebutanoicacid,α,γ-dioxo-,methylester

N-(2-((4-(1,1-Difluoroethyl)oxazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-2-methyl-5-(m-tolyl)oxazole-4-carboxamide

inhibit,ACT389949,Inhibitor,ACT 389949,ACT-389949

N-2-4-(1,1-Difluoro-ethyl)-2-oxazolylmethyl-2H-1,2,3-triazol-4-yl-2-methyl-5-(3-methylphenyl)-4-oxazolecarboxamide

1258417-54-7

C20H18F2N6O3

API