ChemicalBook > CAS DataBase List > Borussertib
Borussertib
- Product Name
- Borussertib
- CAS No.
- 1800070-77-2
- Chemical Name
- Borussertib
- Synonyms
- Borussertib;Borussertib, 10 mM in DMSO;Borussertib,Inhibitor,PKB,Akt,Protein kinase B,inhibit;N-[2-oxo-3-(1-{[4-(5-oxo-3-phenyl-6H-1,6-naphthyridin-2-yl)phenyl]methyl}piperidin-4-yl)-1H-1,3-benzodiazol-5-yl]prop-2-enamide - [AC80954];2-Propenamide, N-[3-[1-[[4-(5,6-dihydro-5-oxo-3-phenyl-1,6-naphthyridin-2-yl)phenyl]methyl]-4-piperidinyl]-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl]-
- CBNumber
- CB14844579
- Molecular Formula
- C36H32N6O3
- Formula Weight
- 596.68
- MOL File
- 1800070-77-2.mol
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Borussertib Property
- Density
- 1.318±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 25 mg/mL (41.90 mM; Need ultrasonic)
- pka
- 10.74±0.20(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0090402
- Product name
- Borussertib
- Purity
- 98.59%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0090402
- Product name
- Borussertib
- Purity
- 98.59%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0090402
- Product name
- Borussertib
- Purity
- 98.59%
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC21869
- Product name
- Borussertib
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1500
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC21869
- Product name
- Borussertib
- Purity
- >98%
- Packaging
- 1g
- Price
- $3000
- Updated
- 2021/12/16
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Borussertib Chemical Properties,Usage,Production
Uses
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1].
References
[1] Niklas Uhlenbrock, et al. Structural and chemical insights into the covalentallosteric inhibition of the protein kinase Akt. Chem Sci., 2019, 10, 3573.
Borussertib Preparation Products And Raw materials
Raw materials
Preparation Products
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