Bractoppin

Product Name: Bractoppin
CAS No.: 2290527-07-8
Chemical Name: Bractoppin
Synonyms: Bractoppin;Bractoppin, 10 mM in DMSO;(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone;Methanone, [4-[(2-fluorophenyl)methyl]-1-piperazinyl](2-phenyl-1H-benzimidazol-6-yl)-;DNA break,Bractoppin,phosphopeptide,inhibit,DNA/RNA Synthesis,DNA damage,RAD51,G2 arrest,Inhibitor,BRCA1 tBRCT
CBNumber: CB14844584
Molecular Formula: C25H23FN4O
Formula Weight: 414.47
MOL File: 2290527-07-8.mol

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Bractoppin Property

Boiling point:: 625.7±65.0 °C(Predicted)
Density: 1.299±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (603.18 mM; Need ultrasonic)
pka: 10.70±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090253
Product name: Bractoppin
Purity: 99.18%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0090253
Product name: Bractoppin
Purity: 99.18%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0090253
Product name: Bractoppin
Purity: 99.18%
Packaging: 25mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0090253
Product name: Bractoppin
Purity: 99.18%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0090253
Product name: Bractoppin
Purity: 99.18%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

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Bractoppin Chemical Properties,Usage,Production

Uses

Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1].

References

[1] Jayaprakash Periasamy, et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Cell Chem Biol. 2018 Jun 21;25(6):677-690.e12. DOI:10.1016/j.chembiol.2018.02.012

Bractoppin Preparation Products And Raw materials

Raw materials

Preparation Products

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Bractoppin Suppliers

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2290527-07-8, BractoppinRelated Search:

Bractoppin

Methanone, [4-[(2-fluorophenyl)methyl]-1-piperazinyl](2-phenyl-1H-benzimidazol-6-yl)-

DNA break,Bractoppin,phosphopeptide,inhibit,DNA/RNA Synthesis,DNA damage,RAD51,G2 arrest,Inhibitor,BRCA1 tBRCT

(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone

Bractoppin, 10 mM in DMSO

2290527-07-8