DB2313 (DB 2313)

Product Name: DB2313 (DB 2313)
CAS No.: 2170606-74-1
Chemical Name: DB2313 (DB 2313)
Synonyms: DB2313;DB2313 （HCl）;DB2313 (DB 2313);DB2313 DB2313.4HCl;1H-Benzimidazole-6-carboximidamide, 2,2'-[(2-fluoro-1,3-phenylene)bis(methyleneoxy-4,1-phenylene)]bis[N-(1-methylethyl)-;2,2'-((((2-Fluoro-1,3-phenylene)bis(methylene))bis(oxy))bis(4,1-phenylene))bis(N-isopropyl-1H-benzo[d]imidazole-6-carboximidamide);2,2'-((((2-Fluoro-1,3-phenylene)bis(methylene))bis(oxy))bis(4,1-phenylene))bis(N-isopropyl-1H-benzo[d]imidazole-6-carboximidamide);2-[4-({2-fluoro-3-[(4-{6-[N-(propan-2-yl)carbamimidoyl]-1H-1,3-benzodiazol-2-yl}phenoxy)methyl]phenyl}methoxy)phenyl]-N-(propan-2-yl)-1H-1,3-benzodiazole-6-carboximidamide
CBNumber: CB14844690
Molecular Formula: C42H41FN8O2
Formula Weight: 708.83
MOL File: 2170606-74-1.mol

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DB2313 (DB 2313) Property

Boiling point:: 880.9±75.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 9.74±0.10(Predicted)
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth

Product number: VLD60674
Product name: DB2313
Packaging: 50mg
Price: $1075
Updated: 2026/06/05

Biosynth

Product number: VLD60674
Product name: DB2313
Packaging: 100mg
Price: $1495
Updated: 2026/06/05

ChemScene

Product number: CS-0087172
Product name: DB2313
Purity: 99.48%
Packaging: 5mg
Price: $162
Updated: 2026/06/04

ChemScene

Product number: CS-0087172
Product name: DB2313
Purity: 99.48%
Packaging: 10mg
Price: $271
Updated: 2026/06/04

ChemScene

Product number: CS-0087172
Product name: DB2313
Purity: 99.48%
Packaging: 25mg
Price: $538
Updated: 2026/06/04

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DB2313 (DB 2313) Chemical Properties,Usage,Production

Uses

DB2313 is a potent inhibitor of transcription factor PU.1. DB2313 inhibits PU.1-dependent reporter gene transactivation with an IC50 of 5 μM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis in acute myeloid leukemia (AML) cells and has anticancer effects[1].

in vivo

DB2313 (17 mg/kg; i.p.; three times per week; for 3 weeks) treatment decreases leukemia progression and results in increased survival in mice^[1].

Animal Model:	NSG mice bearing sublethally irradiated (2.0 Gy) and injection with PU.1 URE^–/– AML cells^[1]
Dosage:	17 mg/kg
Administration:	Intraperitoneal injection; three times per week; for 3 weeks
Result:	Decreased tumor burden and resulted in increased survival.

References

[1] Iléana Antony-Debré, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313. DOI:10.1172/JCI92504
[2] Zhang S, Zhao S, Qi Y, et al. SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner. Mol Ther Nucleic Acids. 2022;27:699-717. DOI:10.1016/j.omtn.2021.12.035

DB2313 (DB 2313) Preparation Products And Raw materials

Raw materials

Preparation Products

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DB2313 (DB 2313) Suppliers

China 28 United States 2 Global 30

Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai SuperLan Chemcial Technique Centre

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ShangHai ChuanQian Chemcial Technique Centre

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Jinan Jiuli Biotechnology Co. , Ltd.

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Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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2170606-74-1, DB2313 (DB 2313)Related Search:

DB2313 (DB 2313)

DB2313

DB2313 （HCl）

1H-Benzimidazole-6-carboximidamide, 2,2'-[(2-fluoro-1,3-phenylene)bis(methyleneoxy-4,1-phenylene)]bis[N-(1-methylethyl)-

2,2'-((((2-Fluoro-1,3-phenylene)bis(methylene))bis(oxy))bis(4,1-phenylene))bis(N-isopropyl-1H-benzo[d]imidazole-6-carboximidamide)

2-[4-({2-fluoro-3-[(4-{6-[N-(propan-2-yl)carbamimidoyl]-1H-1,3-benzodiazol-2-yl}phenoxy)methyl]phenyl}methoxy)phenyl]-N-(propan-2-yl)-1H-1,3-benzodiazole-6-carboximidamide

DB2313 DB2313.4HCl

2,2'-((((2-Fluoro-1,3-phenylene)bis(methylene))bis(oxy))bis(4,1-phenylene))bis(N-isopropyl-1H-benzo[d]imidazole-6-carboximidamide)

2170606-74-1

C42H41FN8O2