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H3B-8800 (H3B8800)

Product Name
H3B-8800 (H3B8800)
CAS No.
1825302-42-8
Chemical Name
H3B-8800 (H3B8800)
Synonyms
H3B-8800 (RVT 2001);H3B-8800 (H3B8800);(2S,3S,6S,7R,10R,E)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-methyl-, (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(1E,3E,5R)-1-methyl-5-(2-pyridinyl)-1,3-hexadien-1-yl]-12-oxooxacyclododec-4-en-6-yl ester
CBNumber
CB14844852
Molecular Formula
C31H45N3O6
Formula Weight
555.71
MOL File
1825302-42-8.mol
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H3B-8800 (H3B8800) Property

Boiling point:
710.6±60.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
solubility 
DMSO: Slightly soluble: 0.1-1 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml
form 
Solid
pka
13.92±0.70(Predicted)
color 
Yellow to orange
InChIKey
YOIQWBAHJZGRFW-WVRLKXNASA-N
SMILES
N1(C(O[C@@H]2[C@@](O)(C)CC[C@@H](O)CC(=O)O[C@H](/C(/C)=C/C=C/[C@H](C3=NC=CC=C3)C)[C@@H](C)C=C2)=O)CCN(C)CC1 |t:32|
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Hazard and Precautionary Statements (GHS)

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H3B-8800 (H3B8800) Chemical Properties,Usage,Production

Uses

H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant[1].

in vivo

H3B-8800 (2, 4 mg/kg; p.o.; daily) shows anti tumor activity in AML derived xenografts (PDXs) with a mutation in SF3B1[1].

Animal Model:6-8 weeks, female NSG or CB17-SCID mice (K562 cells with SF3B1WT or SF3B1K700E)[1]
Dosage:2, 4 mg/kg
Administration:P.o.; daily
Result:Resulted in antileukemic efficacy and splicing modulation in mice bearing AML patient-derived xenografts (PDXs) with a mutation in SF3B1 but had little effect in mice bearing SF3B1WT AML PDXs, significantly reduced leukemic burden relative in SF3B1K700E PDX.

References

[1] Seiler M, et al. H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers. Nat Med. 2018 May;24(4):497-504. DOI:10.1038/nm.4493

H3B-8800 (H3B8800) Preparation Products And Raw materials

Raw materials

Preparation Products

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H3B-8800 (H3B8800) Suppliers

CHINA 28 United States 2 Global 30
Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
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China
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5975
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Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
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China
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2755
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58
ShangHai ChuanQian Chemcial Technique Centre
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15869524721
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3525679403@qq.com
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China
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4899
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58
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
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China
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3505
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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9803
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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9531
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32470
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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Shanghai fuxiang biotechnology co., ltd
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13611719524
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2674347328@qq.com
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China
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1825302-42-8, H3B-8800 (H3B8800)Related Search:


  • H3B-8800 (H3B8800)
  • 1-Piperazinecarboxylic acid, 4-methyl-, (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(1E,3E,5R)-1-methyl-5-(2-pyridinyl)-1,3-hexadien-1-yl]-12-oxooxacyclododec-4-en-6-yl ester
  • H3B-8800 (RVT 2001)
  • (2S,3S,6S,7R,10R,E)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate
  • 1825302-42-8
  • C31H45N3O6