IT603)

Product Name: IT603)
CAS No.: 292168-90-2
Chemical Name: IT603)
Synonyms: IT603);(E/Z)-IT-603;IT-603 (IT 603;c-Rel Inhibitor, IT-603;(E/Z)-IT-603, 10 mM in DMSO;5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one;4-Imidazolidinone, 5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-;GVHD,Inhibitor,Nuclear factor-kappaB,(E/Z)IT603,immunomodulatory,(E/Z) IT 603,disease,inhibit,Nuclear factor-κB,therapy,NF-κB
CBNumber: CB14844913
Molecular Formula: C11H9BrN2O3S
Formula Weight: 329.17
MOL File: 292168-90-2.mol

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IT603) Property

storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (379.74 mM)
form: Solid
color: Light yellow to orange
InChI: 1S/C11H9BrN2O3S/c1-17-8-4-6(12)2-5(9(8)15)3-7-10(16)14-11(18)13-7/h2-4,15H,1H3,(H2,13,14,16,18)
InChIKey: PYLYAEDUIKQBOT-UHFFFAOYSA-N
SMILES: COC1=CC(=CC(=C1O)C=C2C(=O)NC(=S)N2)Br

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.30654
Product name: c-Rel Inhibitor, IT-603
Packaging: 10 mg
Price: $226
Updated: 2025/07/31

ChemScene

Product number: CS-0082234
Product name: (E/Z)-IT-603
Purity: 98.08%
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0082234
Product name: (E/Z)-IT-603
Purity: 98.08%
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0082234
Product name: (E/Z)-IT-603
Purity: 98.08%
Packaging: 25mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0082234
Product name: (E/Z)-IT-603
Purity: 98.08%
Packaging: 50mg
Price: $1450
Updated: 2021/12/16

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IT603) Chemical Properties,Usage,Production

Uses

(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an I?Bα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].

Biological Activity

Cell permeable: yes', 'Primary Target
c-Rel', 'Reversible: yes

References

[1] Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591. DOI:10.1158/2159-8290.CD-13-0585
[2] Huang X, et al. ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway. Front Immunol. 2025 Jan 9;15:1529226. DOI:10.3389/fimmu.2024.1529226

IT603) Preparation Products And Raw materials

Raw materials

Preparation Products

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IT603) Suppliers

China 37 United States 6 Global 43

BOC Sciences

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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd

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Shanghai SuperLan Chemcial Technique Centre

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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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InvivoChem

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Henan Weituxi Chemical Technology Co., Ltd.

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Jinan Jiuli Biotechnology Co. , Ltd.

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292168-90-2, IT603)Related Search:

IT-603 (IT 603

IT603)

4-Imidazolidinone, 5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-

(E/Z)-IT-603

5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one

GVHD,Inhibitor,Nuclear factor-kappaB,(E/Z)IT603,immunomodulatory,(E/Z) IT 603,disease,inhibit,Nuclear factor-κB,therapy,NF-κB

(E/Z)-IT-603, 10 mM in DMSO

c-Rel Inhibitor, IT-603

292168-90-2