ChemicalBook > CAS DataBase List > RG7834 (Synonyms: RO 7020322)

RG7834 (Synonyms: RO 7020322)

Product Name: RG7834 (Synonyms: RO 7020322)
CAS No.: 2072057-17-9
Chemical Name: RG7834 (Synonyms: RO 7020322)
Synonyms: RG7834 S-isomer;RG7834 (RO 7020322);RG78349（RO 7020322）;RG7834, 10 mM in DMSO;RG7834 (Synonyms: RO 7020322);Hepatitis B virus,RG 7834,RG-7834,RO-7020322,RG7834,inhibit,Inhibitor,RO7020322,HBV;(6S)-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6-(propan-2-yl)-2H,6H,7H-pyrido[2,1-a]isoquinoline-3-carboxylic acid;2H-Benzo[a]quinolizine-3-carboxylic acid, 6,7-dihydro-10-methoxy-9-(3-methoxypropoxy)-6-(1-methylethyl)-2-oxo-, (6S)-
CBNumber: CB14845051
Molecular Formula: C22H27NO6
Formula Weight: 401.45
MOL File: 2072057-17-9.mol

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RG7834 (Synonyms: RO 7020322) Property

Boiling point:: 578.6±50.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);249.1(Max Conc. mM)
form: Solid
pka: 5.91±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0084529
Product name: RG7834
Purity: 99.29%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0084529
Product name: RG7834
Purity: 99.29%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0084529
Product name: RG7834
Purity: 99.29%
Packaging: 50mg
Price: $630
Updated: 2021/12/16

ChemScene

Product number: CS-0084529
Product name: RG7834
Purity: 99.29%
Packaging: 100mg
Price: $1050
Updated: 2021/12/16

DC Chemicals

Product number: DC20005
Product name: RG7834(RO7020322)
Purity: >98%
Packaging: 250mg
Price: $1200
Updated: 2021/12/16

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RG7834 (Synonyms: RO 7020322) Chemical Properties,Usage,Production

Uses

RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells[1].

in vivo

RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice^[1].
RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, with a half-life of 4.9 h in mice^[1].

Animal Model:	HBV-infected human liver chimeric uPA-SCID mice^[1]
Dosage:	4 mg/kg
Administration:	Twice daily for 21 days
Result:	Reduced both HBsAg and HBeAg, also decreased serum HBV DNA by 0.6 log10 in mice.

References

[1] Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4. DOI:10.1021/acs.jmedchem.8b01245

RG7834 (Synonyms: RO 7020322) Preparation Products And Raw materials

Raw materials

Preparation Products

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2072057-17-9, RG7834 (Synonyms: RO 7020322)Related Search:

RG7834 (Synonyms: RO 7020322)

RG7834 (RO 7020322)

2H-Benzo[a]quinolizine-3-carboxylic acid, 6,7-dihydro-10-methoxy-9-(3-methoxypropoxy)-6-(1-methylethyl)-2-oxo-, (6S)-

RG7834 S-isomer

RG78349（RO 7020322）

Hepatitis B virus,RG 7834,RG-7834,RO-7020322,RG7834,inhibit,Inhibitor,RO7020322,HBV

(6S)-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6-(propan-2-yl)-2H,6H,7H-pyrido[2,1-a]isoquinoline-3-carboxylic acid

RG7834, 10 mM in DMSO

2072057-17-9