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XRK3F2

Product Name
XRK3F2
CAS No.
2375193-43-2
Chemical Name
XRK3F2
Synonyms
XRK3F2;XRK3F2,XRK-3F2;XRK3F2, 10 mM in DMSO
CBNumber
CB14845071
Molecular Formula
C23H24ClF2NO3
Formula Weight
435.9
MOL File
2375193-43-2.mol
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XRK3F2 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 150 mg/mL (344.12 mM);Water : 0.91 mg/mL (2.09 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H320Causes eye irritation

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb572981
Product name
XRK3F2
Purity
>98%
Packaging
100mg
Price
$690.2
Updated
2021/12/16
Biorbyt Ltd
Product number
orb572981
Product name
XRK3F2
Purity
>98%
Packaging
250mg
Price
$1356.6
Updated
2021/12/16
Biorbyt Ltd
Product number
orb572981
Product name
XRK3F2
Purity
>98%
Packaging
1g
Price
$2691.1
Updated
2021/12/16
DC Chemicals
Product number
DC12331
Product name
XRK3F2
Purity
>98%
Packaging
1g
Price
$1800
Updated
2021/12/16
DC Chemicals
Product number
DC12331
Product name
XRK3F2
Purity
>98%
Packaging
250mg
Price
$900
Updated
2021/12/16
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XRK3F2 Chemical Properties,Usage,Production

Uses

XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain.

Biological Activity

XRK3F2 is a p62-ZZ inhibitor that blunts multiple myeloma (MM)-induced Runx2 inhibition in vitro and induces new bone formation and remodeling in the presence of tumors in vivo.

in vivo

In vivo, XRK3F2 induces new bone formation and remodeling in tumors. The half-life of it in mice was 10.3 hours. In bone with multiple myeloma, it induced significant local new bone formation, but not in mice not directly inoculated with multiple myeloma cells.

target

TargetValue
p62-ZZ
()

References

[1] Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344. DOI:10.3389/fendo.2018.00344

XRK3F2 Preparation Products And Raw materials

Raw materials

Preparation Products

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XRK3F2 Suppliers

China 23 India 1 United States 4 Global 28
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
sales@linyuepharm.com
Country
China
ProdList
5006
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4858
Advantage
58
Hefei Mokai Pharmaceutical Technology Co., Ltd
Tel
18130062233
Email
3362556465@qq.com
Country
China
ProdList
8100
Advantage
58
Shanghai Taopu Industrial Co., LTD
Tel
159-00573766 18018507602
Email
394643792@qq.com
Country
China
ProdList
4386
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58

2375193-43-2, XRK3F2Related Search:


  • XRK3F2
  • XRK3F2,XRK-3F2
  • XRK3F2, 10 mM in DMSO
  • 2375193-43-2