Peficitinib hydrobromide

Product Name: Peficitinib hydrobromide
CAS No.: 1353219-05-2
Chemical Name: Peficitinib hydrobromide
Synonyms: Peficitinib Hydrobromid;Peficitinib hydrobromide;Peficitinib hydrobromide (JAN/USAN);anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide;4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer
CBNumber: CB14848254
Molecular Formula: C18H22N4O2. HBr
Formula Weight: 407.31
MOL File: 1353219-05-2.mol

More

Less

Peficitinib hydrobromide Property

InChI: InChI=1S/C18H22N4O2.BrH/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10;/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22);1H
InChIKey: ZUVPMAPXNYGJQC-UHFFFAOYSA-N
SMILES: N(C1C(=CN=C2NC=CC=12)C(=O)N)C1C2CC3CC(O)(C2)CC1C3.Br

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Peficitinib hydrobromide Chemical Properties,Usage,Production

Uses

Peficitinib (ASP015K) hydrobromide is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1].

Mechanism of action

Peficitinib hydrobromide potently inhibits the JAK-STAT pathway and blocks the signaling of pro-inflammatory cytokines such as IL-6 and IFN-γ. It has the strongest inhibitory activity against JAK3 (IC₅₀ = 0.7 nM), while also taking into account other subtypes (JAK1/2/Tyk2 IC₅₀ 3.9–5.0 nM).

Synthesis

Synthesis of Peficitinib hydrobromide

in vivo

Peficitinib hydrobromide (1-30 mg/kg; p.o.; once daily for 24 days) shows dose-dependent efficacy both in prophylactic and therapeutic dosing regimens in an adjuvant-induced arthritis rat model^[1].

Animal Model:	Seven-weeks-old female Lewis rats, adjuvant-induced arthritis (AIA) model^[1]
Dosage:	1, 3, 10, and 30 mg/kg
Administration:	Oral administration, once daily for 24 days
Result:	Significantly inhibited the increase in paw volume at doses of 1 mg/kg or greater with an ED₅₀ value of 2.7 mg/kg (95% confidence interval: 1.5–4.2 mg/kg). Significantly reduced the bone destruction score at 10 mg/kg or greater and almost fully ameliorated both paw swelling and bone destruction scores at 30 mg/kg.

IC 50

JAK3: 0.7 nM (IC₅₀); JAK1: 3.9 nM (IC₅₀); Tyk2: 4.8 nM (IC₅₀); JAK2: 5 nM (IC₅₀)

References

[1] Ito M, et al. A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model. J Pharmacol Sci. 2017 Jan;133(1):25-33. DOI:10.1016/j.jphs.2016.12.001

Peficitinib hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Peficitinib hydrobromide Suppliers

China 37 India 2 United States 2 Global 41

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 474
Advantage: 55

Nanjing Yikangda Pharmaceutical Technology Co.LTD

Tel: 18118984557; 18118984557
Email: 753016615@qq.com
Country: China
ProdList: 472
Advantage: 58

Tsingxin Biopharmaceutical Co., Ltd

Tel: 18908011947
Email: 3903467217@qq.com
Country: China
ProdList: 134
Advantage: 58

Jiangsu Vcare PharmaTech Co., Ltd.

Tel: 025-58741518 13327700685
Fax: +86-25-58744115
Email: sales@vcarepharmatech.com
Country: China
ProdList: 308
Advantage: 61

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 13316949107 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 9564
Advantage: 58

Chengdu D-innovation Pharmaceutical Co.，LTD

Tel: 028-85929779 18881048017
Email: chenxuanruo@d-innovation.com
Country: China
ProdList: 262
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

Anqing Benro pharmachem Technology Co.,Ltd.

Tel: 05565209906 15391842992
Email: 794263564@qq.com
Country: China
ProdList: 123
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

More

Less

View Lastest Price from Peficitinib hydrobromide manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Peficitinib hydrobromide 1353219-05-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-11-12

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Peficitinib Hydrobromide 1353219-05-2
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2025-09-10

Shaanxi Dideu New Materials Co. Ltd

Product: Peficitinib hydrobromide 1353219-05-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-12

1353219-05-2, Peficitinib hydrobromideRelated Search:

Peficitinib hydrobromide (JAN/USAN)

Peficitinib hydrobromide

4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer

Peficitinib Hydrobromid

anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide

1353219-05-2

C18H22N4O2HBr