4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Product Name: 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS No.: 2138439-12-8
Chemical Name: 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms: Thalidomide-NH-PEG1-NH2;Thalidomide-NH-PEG1-C2-NH2;Thalidomide-4-NH-PEG1-C2-NH2;4-[[2-(2-Aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[(2-(2-aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber: CB14849372
Molecular Formula: C17H20N4O5
Formula Weight: 360.36
MOL File: 2138439-12-8.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: 027588
Product name: Thalidomide-NH-PEG1-C2-NH2
Packaging: 002
Price: $900
Updated: 2021/12/16

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4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties,Usage,Production

Description

Thalidomide-NH-PEG1-C2-NH2 is a Thalidomide -based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.

4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials

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View Lastest Price from 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione manufacturers

Career Henan Chemical Co

Product: 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2138439-12-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 200kg
Release date: 2019-08-30

2138439-12-8, 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneRelated Search:

4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

Thalidomide-NH-PEG1-C2-NH2

Thalidomide-NH-PEG1-NH2

4-[[2-(2-Aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione

Thalidomide-4-NH-PEG1-C2-NH2

4-[(2-(2-aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

2138439-12-8