ChemicalBook > CAS DataBase List > Fmoc-NMe-PEG4-acid

Fmoc-NMe-PEG4-acid

Product Name
Fmoc-NMe-PEG4-acid
CAS No.
2170240-98-7
Chemical Name
Fmoc-NMe-PEG4-acid
Synonyms
Fmoc-NMe-PEG4-acid;Fmoc-NMe-PEG4-C2-acid;Fmoc-MeN-PEG4-CH2CH2COOH;Fmoc-NMe-PEG4-CH2CH2COOH;Fmoc-NMe-PEG4-acid USP/EP/BP;Fmoc-NMe-PEG4-propionic acid;2-Fmoc-5,8,11,14-tetraoxa-2-azaheptadecan-17-oic Acid;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 2-methyl-, 1-(9H-fluoren-9-ylmethyl) ester
CBNumber
CB14849594
Molecular Formula
C27H35NO8
Formula Weight
501.57
MOL File
2170240-98-7.mol
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Fmoc-NMe-PEG4-acid Property

storage temp. 
Storage temp. 2-8°C
solubility 
Soluble in DMSO, DCM, DMF
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-23882
Product name
Fmoc-NMe-PEG4-acid
Purity
98%
Packaging
100mg
Price
$320
Updated
2021/12/16
BroadPharm
Product number
BP-23882
Product name
Fmoc-NMe-PEG4-acid
Purity
98%
Packaging
250mg
Price
$540
Updated
2021/12/16
BroadPharm
Product number
BP-23882
Product name
Fmoc-NMe-PEG4-acid
Purity
98%
Packaging
500mg
Price
$780
Updated
2021/12/16
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Fmoc-NMe-PEG4-acid Chemical Properties,Usage,Production

Description

Fmoc-NMe-PEG4-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Fmoc-NMe-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Fmoc-NMe-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-NMe-PEG4-acid Suppliers

Chengdu Pukang Biotechnology Co., Ltd
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View Lastest Price from Fmoc-NMe-PEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Fmoc-NMe-PEG4-acid 2170240-98-7
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-25