Avibactam Impurity 46

Product Name: Avibactam Impurity 46
CAS No.: 1804915-68-1
Chemical Name: Avibactam Impurity 46
Synonyms: WCK4234;Avibactam Impurity 46;WCK-4234 sodium, 10 mM in DMSO;Avibactam Impurity 67 Sodium Salt;sodium (2R,5R)-2-cyano-7-oxo-6-azabicyclo[3.2.1]octan-6-yl sulfate;Sulfuric acid, mono[(1R,2S,5R)-2-cyano-7-oxo- 1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sodium salt (1:1);inhibit,carbapenemases,antibacterial,KPC enzymes,diazabicyclooctanes (DBOs),Enterobacteriaceae,Bacterial,Inhibitor
CBNumber: CB14869651
Molecular Formula: C7H10N3NaO5S
Formula Weight: 271.22
MOL File: 1804915-68-1.mol

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Avibactam Impurity 46 Property

storage temp.: -20°C, away from moisture
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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Avibactam Impurity 46 Chemical Properties,Usage,Production

Biological Activity

WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases[1][2].

References

[1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01666-19. [2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695.

Avibactam Impurity 46 Preparation Products And Raw materials

Raw materials

Preparation Products

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Avibactam Impurity 46 Suppliers

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1804915-68-1, Avibactam Impurity 46Related Search:

Avibactam Impurity 46

sodium (2R,5R)-2-cyano-7-oxo-6-azabicyclo[3.2.1]octan-6-yl sulfate

WCK4234

Sulfuric acid, mono[(1R,2S,5R)-2-cyano-7-oxo- 1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sodium salt (1:1)

inhibit,carbapenemases,antibacterial,KPC enzymes,diazabicyclooctanes (DBOs),Enterobacteriaceae,Bacterial,Inhibitor

Avibactam Impurity 67 Sodium Salt

WCK-4234 sodium, 10 mM in DMSO

1804915-68-1