ChemicalBook > CAS DataBase List > N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride

N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride

Product Name
N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride
CAS No.
1803003-68-0
Chemical Name
N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride
Synonyms
RN 9893;PM-0025;RN9893 HCl;RN-9893 HCl;RN 9893 HCl;RN-9893 >=98% (HPLC);RN 9893 hydrochloride;N-(4-((4-isopropylpiperazin-1-yl)sulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide;Benzamide, N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)-;RN9893 Hydrochloride|||RN 9893 HCl|||RN-9893 HCl|||RN-9893|||RN-9893 Hydrochloride|||RN 9893 Hydrochloride
CBNumber
CB14902921
Molecular Formula
C21H23F3N4O5S
Formula Weight
500.49
MOL File
1803003-68-0.mol
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N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride Property

Density 
1.421±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 25mg/mL, clear
pka
11.01±0.70(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29172
Product name
RN-9893 (hydrochloride)
Packaging
1mg
Price
$29
Updated
2021/12/16
Cayman Chemical
Product number
29172
Product name
RN-9893 (hydrochloride)
Packaging
5mg
Price
$94
Updated
2021/12/16
Tocris
Product number
5678
Product name
RN9893hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$168
Updated
2021/12/16
Tocris
Product number
5678
Product name
RN9893hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$704
Updated
2021/12/16
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N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride Chemical Properties,Usage,Production

Uses

RN 9893 Hydrochloride is a selective TRPV4 inhibitor.

Biological Activity

RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC50 values of 420 nM, 660 nM, and 320 nM for human, r at and mouse TRPV4 receptors, respectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 μM, an IC50 >30 μM against TRPV3, an IC50 of approximately 30 μM against TRPM8, and also good selectivity using 54 binding assays against common biological targets.

N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride Suppliers

China 22 United Kingdom 1 United States 1 USA 1 Global 25
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9804
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7316
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30233
Advantage
58
Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd.
Tel
020-89854820
Email
sales@jzpharma.cn
Country
China
ProdList
1130
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shenzhen Roark Pharma-Tec Co., Ltd.
Tel
13128912434
Email
2880126944@qq.com
Country
China
ProdList
2577
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 15162312715
Email
sales@szzxbio.com
Country
China
ProdList
2989
Advantage
58
Tel
400-821-026
Email
sangon@qq.com
Country
China
ProdList
47239
Advantage
58

1803003-68-0, N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochlorideRelated Search:


  • N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride
  • RN 9893 hydrochloride
  • Benzamide, N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)-
  • RN-9893 >=98% (HPLC)
  • RN 9893 HCl
  • RN9893 HCl
  • RN-9893 HCl
  • PM-0025
  • RN 9893
  • RN9893 Hydrochloride|||RN 9893 HCl|||RN-9893 HCl|||RN-9893|||RN-9893 Hydrochloride|||RN 9893 Hydrochloride
  • N-(4-((4-isopropylpiperazin-1-yl)sulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide
  • 1803003-68-0
  • C21H23F3N4O5S