ISOMITRAPHYLLINE

Product Name: ISOMITRAPHYLLINE
CAS No.: 4963-01-3
Chemical Name: ISOMITRAPHYLLINE
Synonyms: ISOMITRAPHYLLINE;7-Isomitraphylline;Isomitraphylline-RM;AJMALICIN OXINDOLE A;ISOMITRAPHYLLINE(SH);Ajmalicine oxindole A;(7S)-19α-Methyl-2-oxoformosanan-16-carboxylic acid methyl ester;Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]indolizine]-4'-carboxylic acid, 1,2,5',5'a,7',8',10',10'a-octahydro-1'-methyl-2-oxo-, methyl ester, (1'S,3S,4'aS,5'aS,10'aR)-
CBNumber: CB1490378
Molecular Formula: C21H24N2O4
Formula Weight: 368.43
MOL File: 4963-01-3.mol

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ISOMITRAPHYLLINE Property

Boiling point:: 555.2±50.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Chloroform: Sparingly soluble: 1-10 mg/ml
pka: 13.56±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89718
Product name: Isomitraphylline
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $536
Updated: 2025/07/31

TRC

Product number: I821363
Product name: Isomitraphylline
Packaging: 10mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003036
Product name: ISOMITRAPHYLLINE
Purity: 95.00%
Packaging: 5MG
Price: $504
Updated: 2021/12/16

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ISOMITRAPHYLLINE Chemical Properties,Usage,Production

Description

This Mitragyna alkaloid has been isolated from the leaves of M. speciosa Korth by Beckett and his colleagues. It is an amorphous solid which cannot be obtained crystalline. The base may be characterized as the picrate which forms pale yellow needles from MeOH, m.p. 223°C (dec.). A methylgroup, a methoxycarbonyl group and one imino group are present. The second nitrogen atom is tertiary.

Uses

Isomitraphylline is an oxoindole alkaloid derivied from amazonian plants and maintain medicinal benefits. Used in the treatment of ulcers, arthritis, etc.

Biological Activity

Isomitraphylline, an oxindole alkaloid, has potent anti-cancer activity.

References

[1] Beckett et al., J. Pharm. Pharmacol., 17,753 (1965)
[2] Beckett et ai., Planta Med., 14, 266 (1966)
[3] Structure:
[4] Finch, Taylor., J. Amer. Chem. Soc., 84,3871 (1962)
[5] Prepara tion:
[6] Seaton et al., Can. J. Chem., 38, 1035 (1960)
[7] [1] L DINAN. Assessment of natural products in the Drosophila melanogaster B(II) cell bioassay for ecdysteroid agonist and antagonist activities.[J]. Psychological Reports, 2001, 8 1: 321-342. DOI: 10.1007/pl00000859

[8] [2] NICOLE BACHER. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells[J]. British Journal of Haematology, 2006, 132 5: 615-622. DOI: 10.1111/j.1365-2141.2005.05907.x

ISOMITRAPHYLLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOMITRAPHYLLINE Suppliers

China 33 United Kingdom 2 United States 6 Global 41

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4963-01-3, ISOMITRAPHYLLINERelated Search:

Oxindole ISOMITRAPHYLLINE(P) ISOMITRAPHYLLINE SNAP-N-SHOOT 0.1mg/mL(P) CHEMBRDG-BB 4002906 3-AMINOMETHYL-1,3-DIHYDRO-INDOL-2-ONE 2-METHYL-3-PYRROLIDIN-1-YL-PROPAN-1-OL 1-(3-METHOXYPROPYL)-3-PYRROLIDINYL]METHANAMINE ISOMITRAPHYLLINE CHEMBRDG-BB 4002903 alpha-Phenylpiperidine-2-acetamide

AJMALICIN OXINDOLE A

(7S)-19α-Methyl-2-oxoformosanan-16-carboxylic acid methyl ester

7-Isomitraphylline

Ajmalicine oxindole A

ISOMITRAPHYLLINE(SH)

ISOMITRAPHYLLINE

Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]indolizine]-4'-carboxylic acid, 1,2,5',5'a,7',8',10',10'a-octahydro-1'-methyl-2-oxo-, methyl ester, (1'S,3S,4'aS,5'aS,10'aR)-

Isomitraphylline-RM

4963-01-3