ChemicalBook > CAS DataBase List > BAY 61-3606

BAY 61-3606

Product Name
BAY 61-3606
CAS No.
732983-37-8
Chemical Name
BAY 61-3606
Synonyms
CS-2745;BAY-61-360;BAY 61-3606;SYK INHIBITOR IV;BAY 61-3606 free base;BAY 61-3606 (BAY61-3606);BAY 61-3606, 10 mM in DMSO;Syk Inhibitor IV, BAY 61-3606;Syk Inhibitor IV, BAY 61-3606 HCl;BAY 61-3606 hydrate hydrochloride
CBNumber
CB1497948
Molecular Formula
C20H18N6O3
Formula Weight
390.4
MOL File
732983-37-8.mol
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BAY 61-3606 Property

Density 
1.41
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
solid
color 
yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
574714
Product name
Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem
Packaging
2mg
Price
$236
Updated
2025/07/31
TRC
Product number
S920058
Product name
SykInhibitorIV
Packaging
2.5mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
A3227
Product name
BAY61-3606
Packaging
5mg
Price
$140
Updated
2021/12/16
ApexBio Technology
Product number
A3227
Product name
BAY61-3606
Packaging
10mg
Price
$240
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000047
Product name
BAY 61-3606 HYDROCHLORIDE HYDRATE
Purity
95.00%
Packaging
5MG
Price
$858.22
Updated
2021/12/16
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BAY 61-3606 Chemical Properties,Usage,Production

Uses

Syk Inhibitor IV is an imidazopyrimidine inhibitor of Syk and Syk-mediated functions.

Definition

ChEBI: 2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide is a member of pyrimidines.

Biological Activity

Cell permeable: yes', 'Primary Target
Syk', 'Product competes with ATP.', 'Reversible: yes

in vivo

Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor[4].

Animal Model:Female BALB/c nude mice (5 weeks old) bearing MCF-7 tumor xenograft[4]
Dosage:50 mg/kg
Administration:Injected intraperitoneally twice a week with Bay 61-3606 (50 mg/kg), TRAIL (10 mg/kg) or a combination of Bay 61-3606 (50 mg/kg) and TRAIL (10 mg/kg); TRAIL was given 2 h after the injection of Bay 61-3606; for two weeks
Result:Led to efficacious reductions in tumor growth.

BAY 61-3606 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY 61-3606 Suppliers

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732983-37-8, BAY 61-3606Related Search:

Benzyl alcohol 2-Methoxyphenylacetic acid 4'-Hydroxyacetophenone Sodium benzoate Imidazo[1,2-c]pyrimidine, 7-methyl- (9CI) BAY 61-3606

  • BAY 61-3606 free base
  • CS-2745
  • Syk Inhibitor IV, BAY 61-3606: sc-202351 hydrochloride
  • Syk Inhibitor IV, BAY 61-3606 HCl
  • BAY 61-3606
  • BAY 61-3606 hydrate hydrochloride
  • 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide
  • BAY-61-360
  • Syk Inhibitor IV, BAY 61-3606
  • SYK INHIBITOR IV
  • 3-Pyridinecarboxamide, 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-
  • Spleen tyrosine kinase,Syk,inhibit,BAY 61 3606,Apoptosis,Inhibitor,BAY 613606,BAY 61-3606
  • 2-((7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide
  • 2-{[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}pyridine-3-carboxamide
  • BAY 61-3606, 10 mM in DMSO
  • BAY 61-3606 (BAY61-3606)
  • 732983-37-8