OXAZOLAM METHANOL SOLUTION
- Product Name
- OXAZOLAM METHANOL SOLUTION
- CAS No.
- 24143-17-7
- Chemical Name
- OXAZOLAM METHANOL SOLUTION
- Synonyms
- Nebusn;Toccata;Serenal;Tranquit;Hializan;oxazolam;Oxazolazepam;Serenal (Japanese);o-2-methyl-11b-phenyl-;OXAZOLAM METHANOL SOLUTION
- CBNumber
- CB1498314
- Molecular Formula
- C18H17ClN2O2
- Formula Weight
- 328.79
- MOL File
- 24143-17-7.mol
OXAZOLAM METHANOL SOLUTION Property
- Melting point:
- 187°C
- Boiling point:
- 495.8±45.0 °C(Predicted)
- Density
- 1.2065 (rough estimate)
- refractive index
- 1.5400 (estimate)
- Flash point:
- 11 °C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.85±0.60(Predicted)
- form
- A solid
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25-36/38-23/25
- Safety Statements
- 16-36/37-45-24
- Toxicity
- LD50 orl-mus: 5200 mg/kg NYKZAU 66,107,70
- DEA Controlled Substances
- CSCN: 2839
CSA SCH: Schedule IV
NARC: No
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
OXAZOLAM METHANOL SOLUTION Chemical Properties,Usage,Production
Originator
Serenal,Sankyo,Japan,1970
Uses
A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).
Definition
ChEBI: Oxazolam is an organic molecular entity and a hemiaminal ether.
Manufacturing Process
To a solution of 12.0 g of 5-chloro-2-chloroacetylaminobenzophenone and 3.2 g of isopropanolamine in 100 ml of ethanol was added 3.3 g of sodium acetate.
The resulting mixture was heated under reflux with stirring for 12 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off.
The residue was recrystallized from ethanol to give 10.6 g of the desired product melting at 186°C to 188.5°C.
Therapeutic Function
Tranquilizer
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion.An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí and NOx.