6-BROMO-1-METHYL-1H-INDOLE 97
- Product Name
- 6-BROMO-1-METHYL-1H-INDOLE 97
- CAS No.
- 125872-95-9
- Chemical Name
- 6-BROMO-1-METHYL-1H-INDOLE 97
- Synonyms
- 6-BROMO-1-METHYL-1H;6-Bromo-1-methylindole;6-Bromo-1-methylindole 97%;6-BROMO-1-METHYL-1H-INDOLE;1H-Indole, 6-bromo-1-methyl-;6-BROMO-1-METHYL-1H-INDOLE 97;6-Bromo-1-methyl-1H-indole 97%;6-Bromo-1-methyl-1H-indole 95+%
- CBNumber
- CB1501256
- Molecular Formula
- C9H8BrN
- Formula Weight
- 210.07
- MOL File
- 125872-95-9.mol
6-BROMO-1-METHYL-1H-INDOLE 97 Property
- Boiling point:
- 300.9±15.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 125872-95-9
Safety
- Hazard Note
- Harmful
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B808998
- Product name
- 6-bromo-1-methyl-1H-indole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B808998
- Product name
- 6-bromo-1-methyl-1H-indole
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3H32-9-F6
- Product name
- 6-Bromo-1-methyl-1H-indole
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- OR9630
- Product name
- 6-Bromo-1-methyl-1H-indole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- OR9630
- Product name
- 6-Bromo-1-methyl-1H-indole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $28
- Updated
- 2021/12/16
6-BROMO-1-METHYL-1H-INDOLE 97 Chemical Properties,Usage,Production
Synthesis
52415-29-9
74-88-4
125872-95-9
To a round-bottomed flask was added 6-bromo-1H-indole (14.88 g, 76 mmol) and anhydrous THF (150 ml) and stirred until completely dissolved to give a dark maroon solution. The flask was cooled in an ice-water bath and sodium hydride (60 wt% mineral oil dispersion, 3.64 g, 91 mmol) was added in batches over 15 min. The reaction mixture was stirred under ice bath for 20 min and then iodomethane (5.94 ml, 95 mmol) was added slowly through a syringe. Exothermic phenomenon was observed during the addition. After continued stirring for 20 min, the reaction mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved with saturated aqueous sodium bicarbonate solution and subsequently extracted with dichloromethane (3 x 50 ml). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (elution gradient: 0 to 40% ethyl acetate/heptane) to afford 6-bromo-1-methyl-1H-indole (14.44 g, 68.7 mmol, 91% yield) as a light-colored oil. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ=7.51-7.46 (m, 2H), 7.24-7.19 (m, 1H), 7.03 (d, J=3.1Hz, 1H), 6.47 (dd, J=0.9, 3.1Hz, 1H), 3.77 (s, 3H).
References
[1] European Journal of Organic Chemistry, 2011, # 20-21, p. 3781 - 3793
[2] Helvetica Chimica Acta, 2006, vol. 89, # 5, p. 936 - 946
[3] Patent: WO2013/25883, 2013, A1. Location in patent: Page/Page column 41-42
[4] Journal of the American Chemical Society, 2013, vol. 135, # 30, p. 10978 - 10981
[5] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1062 - 1067
6-BROMO-1-METHYL-1H-INDOLE 97 Preparation Products And Raw materials
Raw materials
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