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CYCLACILLIN (200 MG)

Product Name
CYCLACILLIN (200 MG)
CAS No.
3485-14-1
Chemical Name
CYCLACILLIN (200 MG)
Synonyms
wy4508;Calthor;Vipicil;Wyvital;Vatracin;cyclapen;NSC 88789;Citosarin;CICLACILIN;vastcillin
CBNumber
CB1501397
Molecular Formula
C15H23N3O4S
Formula Weight
341.43
MOL File
3485-14-1.mol
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CYCLACILLIN (200 MG) Property

Melting point:
182-183° (anhydrate) (Hou, Poole); mp 156-158° (dec) (Alburn et al.)
alpha 
D25 +268° (water)
Boiling point:
649.6±55.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
pK1, pK2 in water: 2.68, 7.50; in 50% dioxane: 4.16, 7.04(at 25℃)
color 
White to Off-White
Water Solubility 
32g/L(25 ºC)
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C989730
Product name
Cyclacillin
Packaging
1g
Price
$1175
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009112
Product name
CYCLACILLIN
Purity
95.00%
Packaging
5MG
Price
$505.64
Updated
2021/12/16
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CYCLACILLIN (200 MG) Chemical Properties,Usage,Production

Description

Ciclacillin was synthesized by Wyeth Laboratories in 1967 in the course of studies on the improvement of oral absorption of ampicillin. Although its antibacterial activity is one-sixteenth to one-half that of ampicillin, it shows a four to tenfold higher oral absorption and higher urinary excretion. Ciclacillin shows less tendency than ampicillin to cause diarrhea and is used for therapy of pyoderma, wound infection, respiratory and urinary tract infections, as well as ear and nose, and other infections caused by Staphylococcus, Streptococcus, Escherichia coli, Citrobacter, Klebsiella, Proteus, and Haemophilus influenzae.

Originator

UItracillin,Gruenenthal,W. Germany,1972

Uses

Antibacterial.

Uses

Cyclacillin is an aminosalicylic semisynthetic penicillin; Antibiotic.

Definition

ChEBI: Cyclacillin is a penicillin. It has a role as an antibacterial drug.

Manufacturing Process

To 21.6 g (0.10 mol) of 6-aminopenicillanic acid (6-APA) and 213 ml of methylene chloride in a dry 500 ml 3-neck flask fitted with stirrer, thermometer, nitrogen inlet and reflux condenser with drying tube, 25.3 g (0.25 mol) of triethylamine and 13.4 g (0.11 mol) of N,N-dimethylaniline were added. After stirring at reflux for one hour, the mixture was cooled and 21.7 g (0.20 mol) of trimethylchlorosilane was added dropwise at 12° to 15°C
The mixture was refluxed for 45 minutes, cooled under nitrogen, and 19.8 g (0.10 mol) of 1-amino-1-cyclohexane-carboxylic acid chloride HCl was added portionwise at -10°C over 20 minutes. The mixture was stirred for an additional hour while the temperature rose to 20°C. The reaction mixture was poured into 200 ml of cold water with stirring and the two-phase mixture clarified by filtration. Dilute sodium hydroxide solution was added to the filtrate at 5° to 10°C to pH 5.4.
After stirring overnight at room temperature, the crystalline product was collected by filtration, washed with water and finally with acetone, and then dried at 45°C; yield of dihydrate, 29.9 g or 79% of theory based on 6-APA; iodometric assay, 922 mcg per mg; bioassay, 921 mcg per mg, as described in US Patent 3,478,018.

brand name

Cyclapen-W (Wyeth).

Therapeutic Function

Antibacterial

Antimicrobial activity

The structure differs from other aminopenicillins in that the benzene ring is completely saturated and the amino substituent is attached directly to it instead of being linked to an adjacent carbon atom. It is less active than ampicillin against staphylococci, streptococci and H. influenzae, but is better absorbed by mouth, peak plasma levels of 10–18 mg/L being reached after a 500 mg oral dose. Its pharmacokinetic properties, side effects and use resemble those of ampicillin. It has limited availability.

CYCLACILLIN (200 MG) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLACILLIN (200 MG) Suppliers

BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-81138252 +86-18789408387
Fax
029-88380327
Email
1057@dideu.com
Country
China
ProdList
3958
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 13626641628
Email
jiangnan@huidabiotech.com
Country
China
ProdList
3656
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-0571-89903882 15990081639
Email
sunshixuan@huidabiotech.com
Country
China
ProdList
3705
Advantage
58
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View Lastest Price from CYCLACILLIN (200 MG) manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ciclacillin 3485-14-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20T
Release date
2024-07-10

3485-14-1, CYCLACILLIN (200 MG)Related Search:


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