2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID
- Product Name
- 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID
- CAS No.
- 69716-04-7
- Chemical Name
- 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID
- Synonyms
- 6-Hydroxy-3-benzofuranacetic acid;3-Benzofuranacetic acid, 6-hydroxy-;(6-Hydroxybenzofuran-3-yl)acetic acid;2-(6-Hydroxy-1-benzofuran-3-yl)aceticacid;2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97;2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97-3
- CBNumber
- CB1506640
- Molecular Formula
- C10H8O4
- Formula Weight
- 192.17
- MOL File
- 69716-04-7.mol
2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID Property
- Melting point:
- 139-140℃
- Boiling point:
- 251.5±9.0℃ (760 Torr)
- Density
- 1.453±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 105.9±18.7℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.12±0.30(Predicted)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C10H8O4/c11-7-1-2-8-6(3-10(12)13)5-14-9(8)4-7/h1-2,4-5,11H,3H2,(H,12,13)
- InChIKey
- ZEMXZWJZCWCPBM-UHFFFAOYSA-N
- SMILES
- O1C2=CC(O)=CC=C2C(CC(O)=O)=C1
- CAS DataBase Reference
- 69716-04-7
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- H808430
- Product name
- (6-Hydroxy-1-benzofuran-3-yl)aceticAcid
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 0780AC
- Product name
- 2-(6-Hydroxybenzofuran-3-yl)aceticacid
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- CS-M1953
- Product name
- 3-Benzofuranaceticacid,6-hydroxy-
- Packaging
- 25g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- CS-M1953
- Product name
- 3-Benzofuranaceticacid,6-hydroxy-
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- CS-M1953
- Product name
- 3-Benzofuranaceticacid,6-hydroxy-
- Packaging
- 5g
- Price
- $63
- Updated
- 2021/12/16
2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID Chemical Properties,Usage,Production
Uses
(6-Hydroxy-1-benzofuran-3-yl)acetic Acid is a reactant in the synthesis of dihydrobenzofuran (6-{[4''-(2-ethoxyethoxy)-2'',6''-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl)acetic acid as a potent and orally available GPR40/FFA1 agonist.
Synthesis
25392-41-0
69716-04-7
General procedure for the synthesis of 2-(6-hydroxybenzofuran-3-yl)acetic acid from 4-chloromethyl-7-hydroxychromen-2-one: 1. a mixture of 4-chloromethyl-7-hydroxychromen-2-one (21.0 g, 21.0 mmol) with 1 M aqueous sodium hydroxide solution (1 L) was stirred under reflux conditions for 2 hours. 2. After completion of the reaction, the reaction mixture was acidified with concentrated sulfuric acid. 3. The acidified mixture was extracted with ethyl acetate. 4. The extract was washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. 5. The dried organic phase was concentrated under pressure to give the intermediate (6-hydroxy-1-benzofuran-3-yl)acetic acid (18.0 g, 93.75% yield).
References
[1] Heterocycles, 1995, vol. 41, # 4, p. 647 - 650
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 136-137
[3] Patent: WO2008/1931, 2008, A2. Location in patent: Page/Page column 87
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1538 - 1552
[5] Patent: CN104250239, 2016, B. Location in patent: Paragraph 0292; 0293; 0294
2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID manufacturers
- Product
- 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97 69716-04-7
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07