Acalabrutinib Metabolite 27

Product Name: Acalabrutinib Metabolite 27
CAS No.: 2230757-47-6
Chemical Name: Acalabrutinib Metabolite 27
Synonyms: ACP-5862;ACP5862,ACP 5862;Acalabrutinib Impurity 1;Acalabrutinib Metabolite 27;Acalabrutinib Metabolite [AC-5862;Acalabrutinib?active?metabolite?M27;Acalabrutinib Metabolite 27 (ACP-5862);Acalabrutinib Metabolite 27 (Acalabrutinib Impurity 1);4-(8-Amino-3-(4-(but-2-ynamido)butanoyl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide;4-[8-amino-3-[1-oxo-4-[(1-oxo-2-butyn-1-yl)amino]butyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-Benzamide
CBNumber: CB15417707
Molecular Formula: C26H23N7O3
Formula Weight: 481.51
MOL File: 2230757-47-6.mol

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Acalabrutinib Metabolite 27 Property

Density: 1.34±0.1 g/cm3(Predicted)
pka: 11.35±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A621885
Product name: 4-[8-Amino-3-[1-oxo-4-[(1-oxo-2-butyn-1-yl)amino]butyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-benzamide
Packaging: 10mg
Price: $1540
Updated: 2021/12/16

ChemScene

Product number: CS-0111509
Product name: ACP-5862
Purity: 98.09%
Packaging: 50mg
Price: $2800
Updated: 2021/12/16

ChemScene

Product number: CS-0111509
Product name: ACP-5862
Purity: 98.09%
Packaging: 1mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0111509
Product name: ACP-5862
Purity: 98.09%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0111509
Product name: ACP-5862
Purity: 98.09%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

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Acalabrutinib Metabolite 27 Chemical Properties,Usage,Production

Uses

4-[8-Amino-3-[1-oxo-4-[(1-oxo-2-butyn-1-yl)amino]butyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-benzamide is a metabolite of Acalabrutinib (A115605) which is an experimental anti-cancer drug and a selective Bruton''s tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).

in vivo

Following a single oral dose of 100 mg Acalabrutinib, the half‐life of ACP‐5862 is 6.9 hours and the mean exposure is approximately twofold to threefold higher than that of Acalabrutinib^[2].
ACP-5862 (M27) is the major single metabolite in the systemic circulation and accountes for 57.4% and 42.1% of the AUC_0-t total radioactivity in male and female rat plasma, respectively. ACP-5862, the major human metabolite, is a relatively minor component in the systemic circulation and accountes for 6.1% and 8.1% of the AUC_0-t total radioactivity in male and female dog plasma, respectively^[1].
ACP-5862 (1 or 10 μM) has reversible protein binding of 98.6%, 99.8%, 94.3%, 98.6% in mouse, rat, dog, and human plasma^[1].

IC 50

CYP2C8; CYP3A4

Acalabrutinib Metabolite 27 Preparation Products And Raw materials

Raw materials

Preparation Products

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Acalabrutinib Metabolite 27 Suppliers

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2230757-47-6, Acalabrutinib Metabolite 27Related Search:

Aprepitant iMpurity A Aprepitant Acalabrutinib Acalabrutinib D4

Acalabrutinib Metabolite 27

Acalabrutinib?active?metabolite?M27

4-[8-amino-3-[1-oxo-4-[(1-oxo-2-butyn-1-yl)amino]butyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-Benzamide

ACP-5862

Acalabrutinib Impurity 1

Benzamide, 4-[8-amino-3-[1-oxo-4-[(1-oxo-2-butyn-1-yl)amino]butyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-

Acalabrutinib Metabolite (M27) ACP-5862 D4Q: What is Acalabrutinib Metabolite (M27) ACP-5862 D4 Q: What is the CAS Number of Acalabrutinib Metabolite (M27) ACP-5862 D4

Acalabrutinib Metabolite 27 (ACP-5862)

4-(8-Amino-3-(4-(but-2-ynamido)butanoyl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

Acalabrutinib Metabolite 27 (Acalabrutinib Impurity 1)

ACP5862,ACP 5862

Acalabrutinib Metabolite [AC-5862

2230757-47-6