KAN0438757

Product Name: KAN0438757
CAS No.: 1451255-59-6
Chemical Name: KAN0438757
Synonyms: KAN0438757;KAN0438757 (KAN 0438757;KAN0438757, 10 mM in DMSO;inhibit,Autophagy,Inhibitor,KAN0438757,KAN-0438757,KAN 0438757;2-Hydroxyethyl 4-(5'-fluoro-2'-hydroxy-[1,1'-biphenyl]-3-ylsulfonamido)-2-hydroxybenzoate;Benzoic acid, 4-[[(5'-fluoro-2'-hydroxy[1,1'-biphenyl]-3-yl)sulfonyl]amino]-2-hydroxy-, 2-hydroxyethyl ester
CBNumber: CB15430845
Molecular Formula: C21H18FNO7S
Formula Weight: 447.43
MOL File: 1451255-59-6.mol

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KAN0438757 Property

Boiling point:: 680.0±65.0 °C(Predicted)
Density: 1.507±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 130 mg/mL (290.55 mM)
form: Solid
pka: 6.42±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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KAN0438757 Chemical Properties,Usage,Production

Uses

KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM[1].

in vivo

KAN0438757 (i.p., 10; 25; 50 mg/kg) is well tolerated, and shows no relevant systemic toxic effects in C57BL6/N mice^[2].

References

[1] Gustafsson NMS, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018 Sep 24;9(1):3872. DOI:10.1038/s41467-018-06287-x
[2] De Oliveira T, et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. Cancers (Basel). 2021 Feb 28;13(5):1011. DOI:10.3390/cancers13051011

KAN0438757 Preparation Products And Raw materials

Raw materials

Preparation Products

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KAN0438757 Suppliers

China 29 United States 4 Global 33

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai SuperLan Chemcial Technique Centre

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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CR Corporation Limited

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InvivoChem

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai hongqu biomedical technology co. LTD

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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

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InvivoChem

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1451255-59-6, KAN0438757Related Search:

KAN0438757

Benzoic acid, 4-[[(5'-fluoro-2'-hydroxy[1,1'-biphenyl]-3-yl)sulfonyl]amino]-2-hydroxy-, 2-hydroxyethyl ester

inhibit,Autophagy,Inhibitor,KAN0438757,KAN-0438757,KAN 0438757

KAN0438757, 10 mM in DMSO

2-Hydroxyethyl 4-(5'-fluoro-2'-hydroxy-[1,1'-biphenyl]-3-ylsulfonamido)-2-hydroxybenzoate

KAN0438757 (KAN 0438757

1451255-59-6