KAN0438757
- Product Name
- KAN0438757
- CAS No.
- 1451255-59-6
- Chemical Name
- KAN0438757
- Synonyms
- KAN0438757;KAN0438757 (KAN 0438757;KAN0438757, 10 mM in DMSO;inhibit,Autophagy,Inhibitor,KAN0438757,KAN-0438757,KAN 0438757;2-Hydroxyethyl 4-(5'-fluoro-2'-hydroxy-[1,1'-biphenyl]-3-ylsulfonamido)-2-hydroxybenzoate;Benzoic acid, 4-[[(5'-fluoro-2'-hydroxy[1,1'-biphenyl]-3-yl)sulfonyl]amino]-2-hydroxy-, 2-hydroxyethyl ester
- CBNumber
- CB15430845
- Molecular Formula
- C21H18FNO7S
- Formula Weight
- 447.43
- MOL File
- 1451255-59-6.mol
KAN0438757 Property
- Boiling point:
- 680.0±65.0 °C(Predicted)
- Density
- 1.507±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 130 mg/mL (290.55 mM)
- form
- Solid
- pka
- 6.42±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
KAN0438757 Chemical Properties,Usage,Production
Uses
KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM[1].
in vivo
KAN0438757 (i.p., 10; 25; 50 mg/kg) is well tolerated, and shows no relevant systemic toxic effects in C57BL6/N mice[2].
References
[1] Gustafsson NMS, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018 Sep 24;9(1):3872. DOI:10.1038/s41467-018-06287-x
[2] De Oliveira T, et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. Cancers (Basel). 2021 Feb 28;13(5):1011. DOI:10.3390/cancers13051011
KAN0438757 Preparation Products And Raw materials
Raw materials
Preparation Products
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