3-ISOPROPYLISOXAZOL-5-AMINE
- Product Name
- 3-ISOPROPYLISOXAZOL-5-AMINE
- CAS No.
- 88786-11-2
- Chemical Name
- 3-ISOPROPYLISOXAZOL-5-AMINE
- Synonyms
- I80130;5-Amino-3-isopropylisoxazole;3-Amino-5-isopropylisoxazole;3-Isopropyl-isoxazol-5-ylamine;3-Isopropylisoxazol-5-amine ,97%;3-propan-2-yl-5-oxazol-3-iumamine;5-Isoxazolamine, 3-(1-methylethyl)-;[3-(Propan-2-yl)-1,2-oxazol-5-yl]amine;3-isopropyl-5-isoxazolamine(SALTDATA: FREE)
- CBNumber
- CB1547230
- Molecular Formula
- C6H10N2O
- Formula Weight
- 126.16
- MOL File
- 88786-11-2.mol
3-ISOPROPYLISOXAZOL-5-AMINE Property
- Boiling point:
- 239.5±20.0 °C(Predicted)
- Density
- 1.070±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.86±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I918485
- Product name
- 3-Isopropylisoxazol-5-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- JK276726
- Product name
- 3-Isopropylisoxazol-5-amine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 071375
- Product name
- [3-(Propan-2-yl)-1,2-oxazol-5-yl]amine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $262
- Updated
- 2021/12/16
- Product number
- JK276726
- Product name
- 3-Isopropylisoxazol-5-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 071375
- Product name
- [3-(Propan-2-yl)-1,2-oxazol-5-yl]amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $328
- Updated
- 2021/12/16
3-ISOPROPYLISOXAZOL-5-AMINE Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
29509-06-6
88786-11-2
Step 2. Synthesis of 5-amino-3-isopropylisoxazole: Hydroxylamine hydrochloride (10.3 g, 148 mmol) was slowly added to a pre-cooled aqueous solution (73 mL) of NaOH (25.9 g, 645 mmol) under ice bath conditions. Subsequently, the resulting solution was added dropwise to a solution of crude 3-oxo-4-methylpentanenitrile while maintaining stirring. The reaction mixture was heated at 50 °C for 2.5 h. The formation of a yellow oily material with low density was observed during the reaction. Upon completion of the reaction, the reaction mixture was extracted with CHCl3 (3 x 100 mL) while hot without cooling. The organic phases were combined, dried with anhydrous MgSO4 and subsequently concentrated under reduced pressure. The resulting yellow oily solid was purified by a silica gel pad (eluent: 10% acetone/90% CH2Cl2) to afford the target product 5-amino-3-isopropylisoxazole as a yellow solid (11.3 g, 70% yield) with a melting point of 63-65 °C. TLC analysis showed an Rf value of 0.19 (eluent: 5% acetone/95% CH2Cl2).1H-NMR ( DMSO-d6) δ: 1.12 (d, J = 7.0 Hz, 6H), 2.72 (sept, J = 7.0 Hz, 1H), 4.80 (s, 2H), 6.44 (s, 1H).FAB-MS m/z (relative abundance): 127 ((M + H)+; 67%).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1082 - 1105
[2] Patent: US2007/244120, 2007, A1. Location in patent: Page/Page column 13
[3] Synthesis (Germany), 2013, vol. 45, # 2, p. 171 - 173
[4] Patent: EP1047418, 2005, B1. Location in patent: Page/Page column 22
[5] Heterocycles, 1991, vol. 32, # 6, p. 1153 - 1158
3-ISOPROPYLISOXAZOL-5-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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