Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester

Product Name: Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
CAS No.: 1858276-04-6
Chemical Name: Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
Synonyms: TAK-981;Subasumstat;Subasumstat(TAK-981);Subasumstat, 10 mM in DMSO;((1R,2S,4R)-4-((5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate;(1R，2S，4R)-4-{[5-({4-[(1R)-7-chloro-1，2，3，4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate;(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate;Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester;inhibit,Ubiquitin ligase,E1/E2/E3 Enzyme,Subasumstat,TAK 981,E1 activating enzyme,Ubiquitin conjugating enzyme,Inhibitor,E2 conjugating enzyme,TAK981,Ubiquitin activating enzyme,E3 ligating enzyme
CBNumber: CB15488093
Molecular Formula: C25H28ClN5O5S2
Formula Weight: 578.1
MOL File: 1858276-04-6.mol

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Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Property

Boiling point:: 836.1±75.0 °C(Predicted)
Density: 1.474±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 16.67 mg/mL (28.84 mM; ultrasonic and warming and heat to 80°C)
form: A solid
pka: 9.35±0.70(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C351340
Product name: TAK-981
Packaging: 2.5mg
Price: $1470
Updated: 2021/12/16

ChemScene

Product number: CS-0091878
Product name: Subasumstat
Purity: 98.56%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0091878
Product name: Subasumstat
Purity: 98.56%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0091878
Product name: Subasumstat
Purity: 98.56%
Packaging: 10mg
Price: $310
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009808
Product name: TAK-981
Purity: 95.00%
Packaging: 5MG
Price: $454.35
Updated: 2021/12/16

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Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Chemical Properties,Usage,Production

Uses

TAK-981 is a heteroaryl sulfamate compound useful as inhibitors of SUMO activating enzyme.

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Suppliers

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TargetMol Chemicals Inc.

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1858276-04-6, Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl esterRelated Search:

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester

TAK-981

(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate

Subasumstat

((1R,2S,4R)-4-((5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate

Subasumstat(TAK-981)

inhibit,Ubiquitin ligase,E1/E2/E3 Enzyme,Subasumstat,TAK 981,E1 activating enzyme,Ubiquitin conjugating enzyme,Inhibitor,E2 conjugating enzyme,TAK981,Ubiquitin activating enzyme,E3 ligating enzyme

(1R，2S，4R)-4-{[5-({4-[(1R)-7-chloro-1，2，3，4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate

Subasumstat, 10 mM in DMSO

1858276-04-6

C25H28ClN5O5S2