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Remdesivir N-2

Product Name
Remdesivir N-2
CAS No.
1191237-80-5
Chemical Name
Remdesivir N-2
Synonyms
GS-5;remdesivir N-2;Remdesivir-015;NSJ-Remdesivir-RS009;Redesivir Impurity 8;Remdesivir Impurity 7;Remdesivir Intermediate 2;Remdesivir Intermediate 4;Remdesivir Related Compound 7;Remdesivir No. 5 Intermediate
CBNumber
CB15493006
Molecular Formula
C15H17N5O4
Formula Weight
331.33
MOL File
1191237-80-5.mol
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Remdesivir N-2 Property

Density 
1.66±0.1 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
solubility 
DMSO:55.5(Max Conc. mg/mL);167.51(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);15.09(Max Conc. mM)
PBS (pH 7.2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM)
DMF:12.0(Max Conc. mg/mL);36.22(Max Conc. mM)
form 
A solid
pka
14.14±0.10(Predicted)
color 
Off-white to light yellow
InChI
InChI=1/C15H17N5O4/c1-14(2)23-11-9(5-21)22-15(6-16,12(11)24-14)10-4-3-8-13(17)18-7-19-20(8)10/h3-4,7,9,11-12,21H,5H2,1-2H3,(H2,17,18,19)/t9-,11-,12-,15+/s3
InChIKey
IJCOKJGMVJGKBB-ULVJVTQWNA-N
SMILES
C([C@@]1(C2=CC=C3C(=NC=NN23)N)O[C@H](CO)[C@@]2([H])OC(C)(C)O[C@@]12[H])#N |&1:1,13,16,23,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0131976
Product name
RemdesivirO-desphosphateacetonideimpurity
Purity
99.88%
Packaging
1mg
Price
$230
Updated
2021/12/16
Ambeed
Product number
A1220957
Product name
(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
Purity
97%
Packaging
100mg
Price
$80
Updated
2021/12/16
Ambeed
Product number
A1220957
Product name
(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
Purity
97%
Packaging
250mg
Price
$115
Updated
2021/12/16
Ambeed
Product number
A1220957
Product name
(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
Purity
97%
Packaging
1g
Price
$285
Updated
2021/12/16
Ambeed
Product number
A1220957
Product name
(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
Purity
97%
Packaging
5g
Price
$1048
Updated
2021/12/16
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Remdesivir N-2 Chemical Properties,Usage,Production

Uses

Remdesivir N-2 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in the research and development and chemical production of Remdesivir.

Synthesis


5.62g of compound GS-441524 was dissolved in 30mL of acetone, 11.50mL of 2,2-dimethoxypropane and 1.34mL of sulfuric acid were added, stirred at 45??C for half an hour, cooled to 25??C, and the organic solvent was removed by rotary evaporation. It was extracted with 100 mL of ethyl acetate and 100 mL of saturated sodium bicarbonate aqueous solution, and the extraction was repeated three times. The ethyl acetate layers were combined, dried by adding anhydrous sodium sulfate, and filtered to remove sodium sulfate. The organic solvent was removed by rotary evaporation, and column chromatography was performed (eluent: petroleum ether/ethyl acetate (V/V)=1/2) to obtain 6.20 g of compound 5 (white solid, 97% yield).

Remdesivir N-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Remdesivir N-2 Suppliers

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View Lastest Price from Remdesivir N-2 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- 1191237-80-5
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-27
Anhui Ruihan Technology Co., Ltd
Product
Remdesivir N-2 1191237-80-5
Price
US $80.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-11
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Remdesivir O-desphosphate acetonide impurity 1191237-80-5
Price
US $5.80/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-24

1191237-80-5, Remdesivir N-2Related Search:

2-ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate Remdesivir Remdesivir impurity2 N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester Remdesivir-003-S

  • 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE-D-ALTRONONITRILE
  • 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-D-Altrononitrile
  • D-ALTRONONITRILE, 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE
  • (3aR,4R,6R,6aR)-4-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • (4R)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • Remdesivir Impurity 7
  • remdesivir N-2
  • GS-5
  • D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-
  • 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-
  • D-Altrononitrile,2-C-(4-aminopyrrolo[2,1-f][1,2,4Chemicalbook]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-
  • Remdesivir Intermediate 2
  • Remdesivir Acetonide Nitrile Impurity
  • (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • Remdesivir Intermediate 4
  • Remdesivir Related Compound 7
  • Remdesivir-015
  • Remdesivir O-desphosphate acetonide impurity
  • (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • (3Ar,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile
  • Remdesivir No. 5 Intermediate
  • (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydr
  • NSJ-Remdesivir-RS009
  • (3ar, 4R, 6R, 6aR) - 4 - (4-aminopyrrole [1,2-f] [1,2,4] triazine-7-yl) - 6 - (hydroxymethyl) - 2,2-dimethyl-tetrahydrofuran [3,4-d] [1,3] dioxazole-4-nitrile
  • Remdesivir Impurity 7 (Remdesivir Acetonide Nitrile Impurity)
  • Remdesivir O-desphosphate acetonide
  • Redesivir Impurity 8
  • 1191237-80-5
  • PEG