FB23

Product Name: FB23
CAS No.: 2243736-35-6
Chemical Name: FB23
Synonyms: FB23;FB23 ，S6291;FB23 inhibitor;FB23, 10 mM in DMSO;2-((2,6-Dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)benzoic acid;Benzoic acid, 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-;2- {[2,6-Dichloro-4- (3,5-dimethyl-1,2-oxazol-4-yl) phenyl] amino} benzoic acid;Inhibitor,FB 23,FB-23,inhibit,anti-proliferative,demethylase,leukemogenesis,FTO,N6-methyladenosine,FB23
CBNumber: CB15574521
Molecular Formula: C18H14Cl2N2O3
Formula Weight: 377.22
MOL File: 2243736-35-6.mol

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FB23 Property

Boiling point:: 488.3±45.0 °C(Predicted)
Density: 1.419±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 2mg/mL, clear
form: Solid
pka: 3.57±0.36(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2695
Product name: FB23
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $131.77
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2695
Product name: FB23
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $539
Updated: 2025/07/31

DC Chemicals

Product number: DC41025
Product name: FB23
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

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FB23 Chemical Properties,Usage,Production

Description

FB23 is a potent and selective inhibitor of N6-methyladenosine (m6A) demethylase FTO (fat mass and obesity associated protein). It moderately inhibits proliferation of NB4 and MONOMAC6 cells. FB23 demonstrates its potent inhibitory impact in AML models.

Uses

FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity[1].

in vivo

A single dose of 3 mg/kg FB23 is i.p. administrated to Sprague Dawley (SD) rats for the pharmacokinetic profile. The C_max and T_max value of FB23 are 142.5 ng/mL and 0.4 hr, respectively^[1].

References

[1] Yue Huang, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. DOI:10.1016/j.ccell.2019.03.006

FB23 Preparation Products And Raw materials

Raw materials

Preparation Products

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FB23 Suppliers

China 40 United States 4 Global 44

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Country: China
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Shanghai Chaolan Chemical Technology Center

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Shanghai SuperLan Chemcial Technique Centre

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Chengdu Saint - Kay Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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2243736-35-6, FB23Related Search:

FB23

Inhibitor,FB 23,FB-23,inhibit,anti-proliferative,demethylase,leukemogenesis,FTO,N6-methyladenosine,FB23

Benzoic acid, 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-

2- {[2,6-Dichloro-4- (3,5-dimethyl-1,2-oxazol-4-yl) phenyl] amino} benzoic acid

FB23, 10 mM in DMSO

FB23 inhibitor

2-((2,6-Dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)benzoic acid

FB23 ，S6291

2243736-35-6