Mal-PEG2-VCP-Eribulin

Product Name: Mal-PEG2-VCP-Eribulin
CAS No.: 2130869-18-8
Chemical Name: Mal-PEG2-VCP-Eribulin
Synonyms: Eribulin+Linker;Mal-PEG2-VCP-Eribulin;Mal-PEG2-VC-PAB-Eribulin;L-Ornithinamide, N-[3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(2S)-2-hydroxy-3-[(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-octacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-5-oxo-11,15:18,21:24,2...;N-[3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(2S)-2-hydroxy-3-[(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-octacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-5-oxo-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2′,3′:5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-2-yl]propyl]amino]carbonyl]oxy]methyl]phenyl]-L-ornithinamide
CBNumber: CB15821148
Molecular Formula: C70H99N7O21
Formula Weight: 1374.59
MOL File: 2130869-18-8.mol

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Mal-PEG2-VCP-Eribulin Property

Density: 1.35±0.1 g/cm3(Predicted)
form: Solid
pka: 11.93±0.46(Predicted)
color: White to off-white
InChIKey: ODAGJGZILCZEBN-SMVXCZSXNA-N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0101608
Product name: Mal-PEG2-VCP-Eribulin
Purity: 95.75%
Packaging: 1mg
Price: $2500
Updated: 2021/12/16

ChemScene

Product number: CS-0101608
Product name: Mal-PEG2-VCP-Eribulin
Purity: 95.75%
Packaging: 5mg
Price: $8500
Updated: 2021/12/16

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Mal-PEG2-VCP-Eribulin Chemical Properties,Usage,Production

Uses

Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates[1][2][3].

IC 50

Traditional Cytotoxic Agents

References

[1] Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.
[2] Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505. DOI:10.1158/0008-5472.CAN-10-1874
[3] Watanabe K, et al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4;10(2):161-174. DOI:10.18632/oncotarget.26536

Mal-PEG2-VCP-Eribulin Preparation Products And Raw materials

Raw materials

Preparation Products

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Mal-PEG2-VCP-Eribulin Suppliers

China 20 United States 1 Global 21

Levena (Suzhou) Biopharma Co., Ltd.

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Email: info@levena.cn
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Shanghai YuanYe Biotechnology Co., Ltd.

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Cool Pharm, Ltd

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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Hangzhou Huarong Pharm Co., Ltd.

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Shanghai Minkai Biological Technology Co., Ltd

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Hubei Soren Technology Co., Ltd

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2130869-18-8, Mal-PEG2-VCP-EribulinRelated Search:

Mal-PEG2-VCP-Eribulin

L-Ornithinamide, N-[3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(2S)-2-hydroxy-3-[(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-octacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-5-oxo-11,15:18,21:24,2...

Mal-PEG2-VC-PAB-Eribulin

Eribulin+Linker

N-[3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(2S)-2-hydroxy-3-[(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-octacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-5-oxo-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2′,3′:5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-2-yl]propyl]amino]carbonyl]oxy]methyl]phenyl]-L-ornithinamide

2130869-18-8

C70H99N7O21

ADC LINKER