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AS2863619

Product Name
AS2863619
CAS No.
2241300-51-4
Chemical Name
AS2863619
Synonyms
AS2863619;AS2863619, 10 mM in DMSO;Cyclin dependent kinase,AS2863619,STAT,AS 2863619,Inhibitor,inhibit,CDK,AS-2863619;4-(1-(2-Methyl-1H-benzo[d]imidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine dihydrochloride
CBNumber
CB15821249
Molecular Formula
C16H13ClN8O
Formula Weight
368.79
MOL File
2241300-51-4.mol
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AS2863619 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 10 mM
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FA176468
Product name
AS 2863619
Packaging
1mg
Price
$210
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA176468
Product name
AS 2863619
Packaging
2mg
Price
$320
Updated
2021/12/16
AK Scientific
Product number
0389EP
Product name
4-[1-(2-Methyl-3H-benzimidazol-5-yl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine;dihydrochloride
Packaging
1mg
Price
$333
Updated
2021/12/16
ChemScene
Product number
CS-0106758
Product name
AS2863619
Purity
>98.0%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0106758
Product name
AS2863619
Purity
>98.0%
Packaging
10mg
Price
$550
Updated
2021/12/16
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AS2863619 Chemical Properties,Usage,Production

Uses

AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene[1].

in vivo

AS2863619 (30 mg/kg; oral administration; daily; for 2 weeks; mice) treatment after sensitization with 2,4-dinitrofluorobenzene (DNFB) dampens the degree of the secondary response, with milder infiltration of inflammatory cells into the skin and decreases ratios of interferon-γ+ (IFN-γ+) cells in a skin contact hypersensitivity model, when compared with vehicle-treated control mice. Treg depletion before the elicitation of the secondary response abolishes AS2863619-induced suppression. KLRG1+ Foxp3+ T cells are specifically increased in DNFB sensitized AS2863619-treated mice[1].

Animal Model:Mice with DNFB-induced contact skin hypersensitivity[1]
Dosage:30 mg/kg
Administration:Oral administration; daily; for 2 weeks
Result:The degree of the secondary response, with milder infiltration of inflammatory cells into the skin and decreased ratios of interferon-γ+ (IFN-γ+) cells.

IC 50

CDK8: 0.61 nM (IC50); CDK19: 4.28 nM (IC50); GSK3α: 76.67 nM (IC50); GSK3β: 63.06 nM (IC50); STAT5

References

[1] Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707. DOI:10.1126/sciimmunol.aaw2707

AS2863619 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS2863619 Suppliers

China 38 United States 5 Global 43
BOC Sciences
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1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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12952
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
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China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
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3008007409@qq.com
Country
China
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86249
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Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
9955
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Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11218
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Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988941452
Fax
QQ：3283937693
Email
YN_research@163.com
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China
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2999
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58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
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5132
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ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
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4887
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2241300-51-4, AS2863619Related Search:


  • AS2863619
  • Cyclin dependent kinase,AS2863619,STAT,AS 2863619,Inhibitor,inhibit,CDK,AS-2863619
  • 4-(1-(2-Methyl-1H-benzo[d]imidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine dihydrochloride
  • AS2863619, 10 mM in DMSO
  • 2241300-51-4