Epertinib hydrochloride
- Product Name
- Epertinib hydrochloride
- CAS No.
- 2071195-74-7
- Chemical Name
- Epertinib hydrochloride
- Synonyms
- S-222611 HCL;Epertinib HCL;S-22611 hydrochloride;Epertinib hydrochloride;Epertinib hydrochloride, 10 mM in DMSO;inhibit,Epidermal growth factor receptor,EGFR,S22611,Epertinib,Epertinib hydrochloride,ErbB-1,HER1,S 22611,S-22611,Inhibitor;(R,Z)-1-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)but-2-yn-1-one O-morpholin-3-ylmethyl oxime hydrochloride
- CBNumber
- CB15821401
- Molecular Formula
- C30H28Cl2FN5O3
- Formula Weight
- 596.48
- MOL File
- 2071195-74-7.mol
Epertinib hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 125 mg/mL (209.56 mM)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
N-Bromosuccinimide Price
- Product number
- 44442
- Product name
- Epertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $55
- Updated
- 2026/04/30
- Product number
- 44442
- Product name
- Epertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $248
- Updated
- 2026/04/30
- Product number
- 44442
- Product name
- Epertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $385
- Updated
- 2026/04/30
- Product number
- 44442
- Product name
- Epertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $619
- Updated
- 2026/04/30
- Product number
- CS-0092330
- Product name
- Epertinib(hydrochloride)
- Purity
- 99.76%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
Epertinib hydrochloride Chemical Properties,Usage,Production
Uses
Epertinib Hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4.
in vivo
Epertinib hydrochloride (0-100 mg/kg, Orally, once daily for 28 days) shows antitumor activity[1].
Epertinib hydrochloride (50 mg/kg, Orally, once daily for 30 days) significantly reduces the brain tumor volume[1].
Epertinib hydrochloride (0-50 mg/kg, Orally, once daily for 10-28 days) significantly inhibits the tumor growth in a dose-dependent manner[2].
| Animal Model: | Nude mice (BALB/cAJcl-nu/nu, implanted intracranially with MDA-MB-361 or BR2 cells)[1] |
| Dosage: | 12.5, 25, 50, 100 mg/kg |
| Administration: | Orally, once daily for 28 days |
| Result: | Showed antitumor activity in the mammary fat pad implantation model using both cell lines and the ED50 values were comparable (24.1mg/kg and 26.5mg/kg for MDA-MB-361 and BR2 (MDA-MB-361-luc-BR2), respectively). |
| Animal Model: | Nude mice (BALB/cAJcl-nu/nu, implanted intracranially with MDA-MB-361 or BR2 cells)[1] |
| Dosage: | 50 mg/kg |
| Administration: | Orally, once daily for 30 days |
| Result: | Significantly reduced the brain tumor volume, indicating that epertinib could have potent antitumor activity in brain metastasis even in the presence of an intact BTB (blood-tumor barrier). |
| Animal Model: | Nude mice (BALB/cAJcl-nu/nu, prepared by subcutaneous implantation of human gastric cancer cells, NCI-N87 into the back of nude mice)[2] |
| Dosage: | 0, 6.25, 12.5, 25, and 50 mg/kg |
| Administration: | Oral gavage, daily for 10-28 days |
| Result: | Significantly inhibited the tumor growth in a dose-dependent manner. |
IC 50
EGFR: 1.48 ± 0.0 nM (IC50); HER4: 2.49 ± 0.1 nM (IC50); HER2: 7.15 nM (IC50)
Epertinib hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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