MMP-9-IN-1

Product Name: MMP-9-IN-1
CAS No.: 502887-71-0
Chemical Name: MMP-9-IN-1
Synonyms: OUN87710;MMP-9-IN-1;OUN87710,MMP-9-IN-1;MMP-9-IN-1, 10 mM in DMSO;N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide;Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-;PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin
CBNumber: CB15821461
Molecular Formula: C16H17F2N3O3S
Formula Weight: 369.39
MOL File: 502887-71-0.mol

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MMP-9-IN-1 Property

Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 125 mg/mL (338.40 mM)
pka: 7.80±0.50(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

DC Chemicals

Product number: 012834
Product name: MMP-9-IN-1
Packaging: 001
Price: $750
Updated: 2021/12/16

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MMP-9-IN-1 Chemical Properties,Usage,Production

Definition

ChEBI: MMP-9-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of [(4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetic acid with the amino group of 4-(difluoromethoxy)aniline. It is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor and an antineoplastic agent. It is an organofluorine compound, an aromatic compound, a pyrimidone, an organic sulfide and a secondary carboxamide.

Biological Activity

MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the heme (PEX) domain of MMP-9 with a Kd of 2.1 μM.

in vivo

MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo.

Animal Model:	4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor
Dosage:	20 mg/kg
Administration:	Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks,
Result:	Resulted in a profound delay in tumor growth. Inhibited cancer cell metastasis.

target

Target	Value
MMP-9 (Cell-free assay)	2.1 μM(Kd)

MMP-9-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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MMP-9-IN-1 Suppliers

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502887-71-0, MMP-9-IN-1Related Search:

MMP-9-IN-1

OUN87710

Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-

OUN87710,MMP-9-IN-1

N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide

PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin

MMP-9-IN-1, 10 mM in DMSO

502887-71-0

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