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ASP4132

Product Name
ASP4132
CAS No.
1640294-30-9
Chemical Name
ASP4132
Synonyms
ASP4132;ASP4132 tosylate;ASP4132, 10 mM in DMSO;anti-cancer,AMPK,xenograft,ASP4132,orally,inhibit,ASP 4132,cancer,breast,AMP-activated protein kinase,Inhibitor,ASP-4132;(6-(1-((6-Methoxypyridin-3-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-yl)(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)methanone bis(4-methylbenzenesulfonate)
CBNumber
CB16187892
Molecular Formula
C39H43F3N6O5S
Formula Weight
764.87
MOL File
1640294-30-9.mol
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ASP4132 Property

solubility 
DMSO:175.0(Max Conc. mg/mL);186.75(Max Conc. mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0129453
Product name
ASP4132
Purity
98.85%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0129453
Product name
ASP4132
Purity
98.85%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0129453
Product name
ASP4132
Purity
98.85%
Packaging
25mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0129453
Product name
ASP4132
Purity
98.85%
Packaging
50mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0129453
Product name
ASP4132
Purity
98.85%
Packaging
100mg
Price
$1250
Updated
2021/12/16
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ASP4132 Chemical Properties,Usage,Production

Uses

(6-(1-((6-Methoxypyridin-3-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-yl)(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)methanone 4-?Methylbenzenesulfona?te (1:2) is an activate of Adenosine Monophosphate-Activated Protein Kinase (AMPK). Used to treat human cancer.

in vivo

ASP4132 (0.5-8 mg/kg; PO; once daily; for 21 days) causes the tumor growth inhibition and regression[1].
ASP4132 (1 mg/kg; IV or PO) has a T1/2 of 3.6 hours, a CLtot of 19 mL/min?kg, and a Vss of 4.6 L/kg for rats for IV[1].
ASP4132 is stable in human liver microsomes (HLM CLint, vitro=61 mL/min?kg)[1].

Animal Model:Five-week-old male nude mice with MDA-MB-453[1]
Dosage:0.5, 1, 2, 4, 8 mg/kg
Administration:PO; once daily; for 21 days
Result:The tumor growth inhibition (TGI) rate was 29% at 1 mg/kg, and the tumor regression rate was 26%, 87% and 96% at 2, 4 and 8 mg/kg, respectively.
Animal Model:Male SD rats[1]
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:IV or PO
Result:Had a T1/2 of 3.6 hours, a CLtot of 19 mL/min?kg, and a Vss of 4.6 L/kg for rats for IV.
Had a Cmax of 72 ng/mL and an AUC24h of 705 ng?h/mL for PO.

IC 50

AMPK: 18 nM (EC50)

ASP4132 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASP4132 Suppliers

China 39 United States 5 Global 44
BOC Sciences
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1-631-485-4226; 16314854226
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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010-50973130 18101056239
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Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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China
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TargetMol Chemicals Inc.
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1640294-30-9, ASP4132Related Search:


  • ASP4132
  • (6-(1-((6-Methoxypyridin-3-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-yl)(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)methanone bis(4-methylbenzenesulfonate)
  • ASP4132 tosylate
  • anti-cancer,AMPK,xenograft,ASP4132,orally,inhibit,ASP 4132,cancer,breast,AMP-activated protein kinase,Inhibitor,ASP-4132
  • ASP4132, 10 mM in DMSO
  • 1640294-30-9
  • C46H51F3N6O8S2