LY 171883
- Product Name
- LY 171883
- CAS No.
- 88107-10-2
- Chemical Name
- LY 171883
- Synonyms
- S-1414;LY 171883;LY-171,833;TOMELUKAST;LY 171883 ISO 9001：2015 REACH;5-[4-4-ACETYL-3-HYDROXY-2-PROPYLPHENOXYBUTYL]-1H-TETRAZOLE;5-[4-(1-ACETYL-2-HYDROXY-3-PROPYLPHENOXY)BUTYL]-1H-TETRAZOLE;2’-hydroxy-3’-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)-acetophenon;1-(2-hydroxy-3-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)phenyl)-ethanon;1-[2-HYDROXY-3-PROPYL-4-[4-(1H-TETRAZOL-5-YL)BUTOXY]PHENYL]ETHANONE
- CBNumber
- CB1666122
- Molecular Formula
- C16H22N4O3
- Formula Weight
- 318.37
- MOL File
- 88107-10-2.mol
LY 171883 Property
- Melting point:
- 117-119℃
- Boiling point:
- 553.0±60.0 °C(Predicted)
- Density
- 1.220±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml),
- form
- White solid.
- pka
- 5.02±0.10(Predicted)
- color
- White
- Stability:
- Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
- CAS DataBase Reference
- 88107-10-2
N-Bromosuccinimide Price
- Product number
- J67028
- Product name
- LY 171883, 98%
- Packaging
- 10mg
- Price
- $165
- Updated
- 2023/06/20
- Product number
- 70710
- Product name
- LY171883
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 70710
- Product name
- LY171883
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $76
- Updated
- 2024/03/01
- Product number
- 70710
- Product name
- LY171883
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $312
- Updated
- 2024/03/01
- Product number
- 70710
- Product name
- LY171883
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $545
- Updated
- 2024/03/01
LY 171883 Chemical Properties,Usage,Production
Description
LY-171883 (88107-10-2) is a selective and orally active leukotriene D4 (LTD4) antagonist (Ki = 0.63 μM).1 It is also an activator of peroxisome proliferator-activated receptors (PPARs).2,3
Uses
LY 171883 is a selective leukotriene D4 antagonist.
Definition
ChEBI: A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti asthmatic activity.
Biological Activity
Selective, orally active leukotriene D 4 (LTD 4 ) antagonist; inhibits binding of [ 3 H]-LTD 4 to guinea pig lung membranes (K i = 0.63 μ M).? Acts as an agonist at peroxisome proliferator-activated receptors (PPARs).
in vitro
in gh(3) cells, ly-171883 was able to reversibly increase the amplitude of ca(2+)-activated k(+) current concentration-dependently with an ec(50) value of 15 μm. moreover, the treatment of ly-171883 to cytosolic face did not affect single channel conductance of large-conductance ca(2+)-activated k(+) channels in excised inside-out patches recorded from gh(3) cells, however, ly-171883 did increase the channel activity. in addition, the ly-171883-stimulated activity of bk(ca) channels was dependent on membrane potential [1].
in vivo
the effect of ly-171883 on the respiratory and cardiovascular changes in endotoxemia was studied in unanesthetized sheep. in group one, ly-171883 at 4 mg/kg was i.v. injected. in group two, escherichia coli endotoxin (1 μg/kg) was infused, and in group three, ly-171883 at 4 mg/kg was administered before and after the same dose of endotoxin. results showed that infusion of ly-171883 in group one did not alter baseline ventilatory and cardiovascular measurements. in group two, a two-phase pulmonary response was found. an early pulmonary hypertension phase with a fall in cardiac index was observed in group three [2].
References
1) Fleisch et al. (1985), LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl)butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist; J. Pharmacol. Exp. Ther., 233 148 2) Foxworthy and Eacho (1991) Effect of the peroxisome proliferator LY171883 on triglyceride accumulation in rats fed a fat-free diet; Biochem. Pharmacol. 42 1487 3) Kliewer et al. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors; Proc. Natl. Acad. Sci .USA 91 7355
LY 171883 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from LY 171883 manufacturers
- Product
- LY 171883 88107-10-2
- Price
- US $1.80/KG
- Min. Order
- 1g
- Purity
- 96%-99%
- Supply Ability
- 1kg/10kg/100kg
- Release date
- 2020-11-11