3-(2-CHLOROPHENYL)PROPIONIC ACID

Product Name: 3-(2-CHLOROPHENYL)PROPIONIC ACID
CAS No.: 1643-28-3
Chemical Name: 3-(2-CHLOROPHENYL)PROPIONIC ACID
Synonyms: 3-(2-CHLOROPHENYL)PROPANOIC ACID;RARECHEM AL BO 0376;O-CHLOROHYDROCINNAMIC ACID;3-(2-Chlorophenyl)propionic;3-(2-chlorophenyl)propanoate;2-Chlorobenzenepropionic acid;2-Chlorobenzenepropanoic acid;3-(2-Chlorophenyl)propionic aci;3-(2-CHLOROPHENYL)PROPIONIC ACID;Benzenepropanoic acid, 2-chloro-
CBNumber: CB1668489
Molecular Formula: C9H9ClO2
Formula Weight: 184.62
MOL File: 1643-28-3.mol

More

Less

3-(2-CHLOROPHENYL)PROPIONIC ACID Property

Melting point:: 94-96°C
Boiling point:: 171°C 10mm
Density: 1.1989 (rough estimate)
refractive index: 1.5242 (estimate)
Flash point:: 171°C/10mm
storage temp.: Sealed in dry,Room Temperature
pka: 4.58(at 25℃)
Appearance: Off-white to light brown Solid
BRN: 1866789
CAS DataBase Reference: 1643-28-3(CAS DataBase Reference)
NIST Chemistry Reference: 3-(2-Chlorophenyl)propionic acid(1643-28-3)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29163990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B405105
Product name: 3-(2-Chlorophenyl)propanoicacid
Packaging: 250mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B405105
Product name: 3-(2-Chlorophenyl)propanoicacid
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 006108
Product name: 3-(2-Chlorophenyl)propionic acid
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: L357
Product name: 3-(2-Chlorophenyl)propionicacid
Packaging: 1g
Price: $14
Updated: 2021/12/16

Matrix Scientific

Product number: 006108
Product name: 3-(2-Chlorophenyl)propionic acid
Purity: 98%
Packaging: 5g
Price: $34
Updated: 2021/12/16

More

Less

3-(2-CHLOROPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

2033-24-1

89-98-5

1643-28-3

The general procedure for the synthesis of o-chlorophenylpropionic acid (3-(2-chlorophenyl)propionic acid) from cyclic (sub)isopropyl malonate and o-chlorobenzaldehyde was as follows: to a three-necked flask equipped with a dropping funnel, a reflux condenser, and a thermometer was added 85% formic acid (8 mL, 180 mmol). After cooling the solution to 5°C, triethylamine (2.7 mL, 27 mmol) was added slowly and dropwise to ensure that the reaction temperature was maintained below 10°C. Subsequently, 2-bromobenzaldehyde (7a, 5 g, 27 mmol) and Meldrum acid (3.9 g, 27 mmol) were added to the reaction system and the mixture was heated to reflux for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into pre-cooled ice water (30 mL). The resulting suspension was acidified to pH ≈ 1 with 5.5 M hydrochloric acid and subsequently placed in a refrigerator overnight. The precipitated crystals were collected by diafiltration, washed with cold water (3 × 20 mL), dried in a desiccator and the product was dissolved in chloroform (100 mL). Insoluble impurities were removed by filtration and the filtrate was concentrated to about 10 mL, after which petroleum ether (15 mL) was added with stirring and the solution was heated. After slow cooling, a white solid was precipitated. A final 4.17 g (67% yield) of the target product was obtained with a melting point of 93-95°C (literature value 99-100°C). The proton NMR spectrum of the product was in agreement with the data reported in literature [8].

References

[1] Synthetic Communications, 1995, vol. 25, # 19, p. 3067 - 3074
[2] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 884 - 892
[3] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 3, p. 670 - 684

3-(2-CHLOROPHENYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Ethanol Sodium Diethyl maleate Benzene Hydrochloric acid 2-Chlorobenzyl bromide Acetic acid PETROLEUM ETHER

Preparation Products

More

Less

3-(2-CHLOROPHENYL)PROPIONIC ACID Suppliers

China 124 Germany 5 India 3 Russia 1 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 12 United States 25 Global 175

Shanghai Tuolei Chemical Reagents Co., Ltd.

Tel: 86-021-50318510
Fax: 021-58650104
Country: China
ProdList: 69
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

New Energy Chemicals

Tel: 0515-82159099 13770142076
Fax: 86-0515-8215909
Email: info@njuchem.com
Country: China
ProdList: 242
Advantage: 65

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from 3-(2-CHLOROPHENYL)PROPIONIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-(2-CHLOROPHENYL)PROPIONIC ACID 1643-28-3
Price: US $31.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-10

Honest Joy Holdings Limited

Product: 3-(2-Chlorophenyl)propanoic acid 1643-28-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.2%
Supply Ability: 100 tons
Release date: 2022-02-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-(2-CHLOROPHENYL)PROPIONIC ACID 1643-28-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

1643-28-3, 3-(2-CHLOROPHENYL)PROPIONIC ACIDRelated Search:

3-(2-Bromophenyl)propionic acid 3-(4-Bromophenyl)propionic acid 3-(2,4-DICHLOROPHENYL)PROPIONIC ACID 3-(2-CHLOROPHENYL)PROPIONIC ACID FMOC-D-2-Chlorophe BOC-(R)-3-AMINO-3-(3-CHLORO-PHENYL)-PROPIONIC ACID METHYL 2-CHLOROBENZOYLACETATE, 97 2-Chloro-L-phenylalanine 2-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID B-(P-CHLOROPHENYL)PROPIONIC ACID,3-(P-CHLOROPHENYL)PROPIONIC ACID,3-(4'-CHLOROPHENYL) PROPIONIC ACID,3-(4-CHLOROPHENYL)PROPIONIC ACID (R)-3-AMINO-3-(4-CHLORO-PHENYL)-PROPIONIC ACID BOC-(S)-3-AMINO-3-(3-CHLORO-PHENYL)-PROPIONIC ACID 3-AMINO-3-(3-CHLORO-PHENYL)-PROPIONIC ACID Methyl (S)-3-acetamido-3-(4-chlorophenyl)propanoate BOC-D-2-Chlorophe BOC-L-2-Chlorophe 3-(3-CHLOROPHENYL)PROPIONIC ACID (R)-2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID HYDROCHLORIDE

3-(2-CHLOROPHENYL)PROPANOIC ACID

3-(2-CHLOROPHENYL)PROPIONIC ACID

RARECHEM AL BO 0376

O-CHLOROHYDROCINNAMIC ACID

3-(2-Chlorophenyl)propionic acid, 98+%

3-(2-chlorophenyl)propanoate

Benzenepropanoic acid, 2-chloro-

3-(2-Chlorophenyl)propionic aci

3-(2-Chlorophenyl)propionic

2-Chlorobenzenepropanoic acid

2-Chlorobenzenepropionic acid

1643-28-3

CARBOXYLIC ACID

Aromatic Propionic Acids