ChemicalBook > CAS DataBase List > METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE

METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE

Product Name: METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE
CAS No.: 35309-35-4
Chemical Name: METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE
Synonyms: Methyl 5-oxoprrolidine-3-carboxylate;4-(Methoxycarbonyl)-2-oxopyrrolidine;Methyl 5-oxo-3-pyrrolidinecarboxylate;METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE;5-oxo-3-pyrrolidinecarboxylic acid methyl ester;5-Oxo-Pyrrolidone-3-carboxylic Acid Methyl ester;5-ketopyrrolidine-3-carboxylic acid methyl ester;5-Oxo-pyrrolidine-3-carboxylic acid methyl ester;3-Pyrrolidinecarboxylic acid, 5-oxo-, Methyl ester
CBNumber: CB1671751
Molecular Formula: C6H9NO3
Formula Weight: 143.14
MOL File: 35309-35-4.mol

Less

METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE Property

Melting point:: 62-64 °C
Boiling point:: 132-142 °C(Press: 0.45 Torr)
Density: 1.204
refractive index: 1.465
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 15.31±0.40(Predicted)
color: Pale Beige to Pale Brown
InChI: InChI=1S/C6H9NO3/c1-10-6(9)4-2-5(8)7-3-4/h4H,2-3H2,1H3,(H,7,8)
InChIKey: FJRTVLWHONLTLA-UHFFFAOYSA-N
SMILES: N1C(=O)CC(C(OC)=O)C1

Less

Safety

HazardClass: IRRITANT
HS Code: 2933998090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: M324690
Product name: Methyl5-Oxopyrrolidine-3-carboxylate
Packaging: 25g
Price: $645
Updated: 2021/12/16

Apolloscientific

Product number: OR300522
Product name: Methyl5-oxopyrrolidine-3-carboxylate
Packaging: 25g
Price: $334
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-1-3A
Product name: Methyl 5-oxopyrrolidine-3-carboxylate
Packaging: 25g
Price: $368
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1051623
Product name: METHYL-5-OXOPYRROLIDINE-3-CARBOXYLATE
Purity: 95.00%
Packaging: 2.5G
Price: $1227.82
Updated: 2021/12/16

AK Scientific

Product number: J99331
Product name: Methyl5-oxopyrrolidine-3-carboxylate
Packaging: 1g
Price: $20
Updated: 2021/12/16

Less

METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Methyl 5-Oxopyrrolidine-3-carboxylate has been used as a reactant in the synthesis of tert-butyloxycarbonyl protected 4,5-methano-β-proline.

Synthesis

1461706-59-1

35309-35-4

General procedure for the synthesis of methyl 5-oxopyrrolidine-3-carboxylate from methyl 1-(benzyloxy)-5-oxopyrrolidine-3-carboxylate: to an autoclave was added methyl 1-(benzyloxy)-5-oxopyrrolidine-3-carboxylate (51.0 g, 0.205 mol), 10% Pd-C catalyst (9.0 g) and methanol (400 mL). The reaction mixture was stirred vigorously at room temperature under 50 atm hydrogen pressure for 24 hours. Upon completion of the reaction, the suspension was filtered to remove the catalyst and the catalyst residue was washed with methanol (2 x 100 mL). The filtrate and washings were combined and the solvent was removed by distillation under reduced pressure to afford the colorless oily product methyl 5-oxopyrrolidine-3-carboxylate (29.2 g, 100% yield), which crystallized upon standing. The melting point of the product was 55-58 °C (literature value 10b 61-62 °C). Mass spectrum (m/z, CI): 287 (M2H+), 144 (MH+). Elemental analysis (C6H9NO3) Calculated values: C 50.35, H 6.34, N 9.79; measured values: C 50.13, H 6.47, N 10.02.1H NMR (500 MHz, DMSO-d6) δ 7.67 (s, 1H), 3.64 (s, 3H), 3.46 (t, J=11.1Hz, 1H), 3.39- 3.31 (m, 2H), 2.43-2.28 (m, 2H).13C NMR (126 MHz, DMSO-d6) δ 175.4,174.0,52.4,44.0,38.4,33.4.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 22, p. 3312 - 3315

METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE Suppliers

China 113 Germany 1 India 2 United Kingdom 2 United States 19 Global 137

Shanghai SunSyn Pharmaceutical Co., Ltd.

Tel: 18621020637 18621020637;
Email: sales@sunsynpharma.com
Country: China
ProdList: 288
Advantage: 55

Jinan Luyuan Biomedical Technology Co., LTD

Tel: 13210587493
Email: jinanluyuan@hotmail.com
Country: China
ProdList: 367
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981
Fax: +86-28-84252965
Email: sales@chembon.com.cn
Country: China
ProdList: 850
Advantage: 64

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Shanghai Sheepchem Co., Ltd.

Tel: +86 (21) 6715-7650
Fax: +86 (21) 6715-7651
Email: sheepchem@163.com
Country: China
ProdList: 994
Advantage: 60

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Modachem Shanghai Co., Ltd

Tel: +86 (0)21 51320687 51371369 1744605818
Fax: +86 (0)21 51371369
Country: China
ProdList: 1578
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Giant chemicals

Tel: 028-85434334 18108076537
Fax: QQ：245797092
Email: market@gianthx.com
Country: China
ProdList: 4505
Advantage: 56

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Suzhou Crst Pharmatech Co., Ltd.

Tel: 0512-62910395 17751098781
Fax: 0512-62910396
Email: sales@crstpharma.com
Country: China
ProdList: 499
Advantage: 58

Nanjing River Chemical Co., Ltd.

Tel: 13951936332 18305166317
Fax: -
Email: info@serpharm.com
Country: China
ProdList: 493
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Shanghai JingSi Biological Technology Co., Ltd

Tel: 18221840760
Fax: QQ:2990760589
Email: 2990760589@qq.com
Country: China
ProdList: 241
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Cck Pharmchem Co.,Ltd

Tel: 0512-68131995 13862051930
Fax: 0512-68131995
Country: China
ProdList: 360
Advantage: 55

Nanjing KaiMubo Pharmaceutical Co., Ltd.

Tel: 025-66162170
Fax: 025-66162170
Country: China
ProdList: 7181
Advantage: 55

Nanjing BAM Biomedical Technology Co., Ltd.

Tel: 18066080842 13952020641
Fax: 025-58912720
Email: bamd@foxmail.com
Country: China
ProdList: 759
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

BIO-PHARMACY (Wuhan) Co., Ltd.

Tel: 0711-5919292 15307133740
Fax: 0711-5919292
Email: 3451683016@qq.com
Country: China
ProdList: 1069
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Jinan Kabotang Biological Technology Co.,Ltd.

Tel: 0531-61320525 15866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 5178
Advantage: 58

Nanjing ChemLin Chemical Industry Co., Ltd.

Tel: 025-83453327
Fax: 025-83453327
Email: product@chemlin.com.cn
Country: China
ProdList: 277
Advantage: 58

Nanjing ChemLin Chemical Industry Co., Ltd.

Tel: 025-83453353
Fax: 025-83453353
Email: nj.chemlin@chemlin.com.cn
Country: CHINA
ProdList: 853
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Nanjing Chengqian Pharmaceutical Technology Co., Ltd.

Tel: 025-52791040 18652036685
Email: haozhongwen@126.com
Country: China
ProdList: 767
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Less

View Lastest Price from METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE 35309-35-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-16

Career Henan Chemical Co

Product: METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE 35309-35-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-20

35309-35-4, METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATERelated Search:

MFCD22689490 ethyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate ethyl 1-(2,5-dioxopyrrolidin-3-yl)piperidine-4-carboxylate ETHYL 1-ETHYL-4,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, 97 Methyl 1-Benzyl-5-oxopyrrolidine-3-carboxylate Methyl 5-Oxo-1-phenylpyrrolidine-3-carboxylate 1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL 1-(2-FURYLMETHYL)-4,5-DIOXOPYRROLIDINE-3-CARBOXYLATE ETHYL 1-(TERT-BUTYL)-4,5-DIOXOPYRROLIDINE-3-CARBOXYLATE 2-(DANSYLSULFONAMIDO)ETHYL-3-(N-SULFOSUCCINIMIDYLCARBOXY)ETHYL DISULFIDE, SODIUM SALT METHYL 1-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)-5-OXO-3-PYRROLIDINECARBOXYLATE 2-[N2-(4-AZIDO-2,3,5,6-TETRAFLUOROBENZOYL)-N6-(6-BIOTINAMIDOCAPROYL)-L-LYSINYL]ETHYL 2'- (N-SULFOSUCCINIMIDYLCARBOXY)ETHYL DISULFIDE, SODIUM SALT METHYL 5-OXO-1-(2-THIENYLMETHYL)PYRROLIDINE-3-CARBOXYLATE METHYL 1-(4-BROMOPHENYL)-5-OXO-3-PYRROLIDINECARBOXYLATE 2-[(N2-[N6-(4-AZIDO-2,3,5,6-TETRAFLUOROBENZOYL)-6-AMINOCAPROYL]-N6-(6-BIOTINAMIDOCAPROYL)-L-LYSINYLAMIDO)] ETHYL 2-(N-SULFOSUCCINIMYDYLCARBOXY)ETHYL DISULFIDE, SODIUM SALT METHYL 1-(4-ETHYLPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE METHYL 1-[2-(1H-INDOL-3-YL)ETHYL]-5-OXO-3-PYRROLIDINECARBOXYLATE METHYL 1-CYCLOHEXYL-5-OXO-3-PYRROLIDINECARBOXYLATE

METHYL 5-OXOPYRROLIDINE-3-CARBOXYLATE

5-Oxo-pyrrolidine-3-carboxylic acid methyl ester

3-Pyrrolidinecarboxylic acid, 5-oxo-, Methyl ester

4-(Methoxycarbonyl)-2-oxopyrrolidine

5-ketopyrrolidine-3-carboxylic acid methyl ester

5-oxo-3-pyrrolidinecarboxylic acid methyl ester

5-Oxo-Pyrrolidone-3-carboxylic Acid Methyl ester

Methyl 5-oxoprrolidine-3-carboxylate

Methyl 5-oxo-3-pyrrolidinecarboxylate

35309-35-4