2-AMINO-5-IODOBENZONITRILE

Product Name: 2-AMINO-5-IODOBENZONITRILE
CAS No.: 132131-24-9
Chemical Name: 2-AMINO-5-IODOBENZONITRILE
Synonyms: 2-Cyano-4-iodoaniline;5-iodoanthranilonitrile;2-AMINO-5-IODOBENZONITRILE;2-aminio-5-iodobenzonitrile;Benzonitrile, 2-amino-5-iodo-
CBNumber: CB1672985
Molecular Formula: C7H5IN2
Formula Weight: 244.03
MOL File: 132131-24-9.mol

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2-AMINO-5-IODOBENZONITRILE Property

Melting point:: 86℃ (ethanol )
Boiling point:: 333.6±37.0 °C(Predicted)
Density: 1.98±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 1.02±0.10(Predicted)
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ACHEMBLOCK

Product number: U139830
Product name: 2-Amino-5-iodobenzonitrile
Purity: 97%
Packaging: 5G
Price: $115
Updated: 2026/05/27

ACHEMBLOCK

Product number: U139830
Product name: 2-Amino-5-iodobenzonitrile
Purity: 97%
Packaging: 25G
Price: $405
Updated: 2026/05/27

Crysdot

Product number: CD12153878
Product name: 2-Amino-5-iodobenzonitrile
Purity: 97%
Packaging: 1g
Price: $145
Updated: 2026/05/27

Crysdot

Product number: CD12153878
Product name: 2-Amino-5-iodobenzonitrile
Purity: 97%
Packaging: 5g
Price: $325
Updated: 2026/05/27

AHH

Product number: MB-03418
Product name: 2-amino-5-iodobenzonitrile
Purity: 97%
Packaging: 5g
Price: $255
Updated: 2026/05/26

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2-AMINO-5-IODOBENZONITRILE Chemical Properties,Usage,Production

Uses

2-Amino-5-iodobenzonitrile is a useful intermediate for the synthesis of lapatinib intermediate of N-[3-chloro-4-3-fluorophenzyloxyphenyl]-6-iodoquinazolin-4-amine.

Synthesis

1885-29-6

132131-24-9

The general procedure for the synthesis of 2-amino-5-iodobenzonitrile from 2-aminobenzonitrile is as follows: 1. A mixture of 2-aminobenzonitrile (0.02 mol) and ammonium iodide (0.02 mol) was dissolved in acetic acid (50 mL). 2. 30% aqueous hydrogen peroxide (0.13 mol) was added dropwise to the above solution slowly at 30 °C. 3. The reaction mixture was stirred at room temperature for 12 hours. 4. For 12 h. 4. After completion of the reaction, the reaction solution was treated with aqueous sodium thiosulfate (40 mL, 0.03 mol) and the pH was adjusted to about 8 by addition of 20% sodium hydroxide solution. 5. The reaction mixture was continued to be stirred at room temperature for 0.5 h. 6. The partially precipitated 2-amino-5- iodobenzonitrile (Product A) was separated by vacuum filtration to give a silvery-white flaky solid in a yield of 92.6%.

References

[1] Acta Crystallographica Section C: Crystal Structure Communications, 2007, vol. 63, # 7, p. o408-o410
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1584 - 1587
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 18, p. 4309 - 4313
[4] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 7, p. 2637 - 2649
[5] Patent: CN103896889, 2016, B. Location in patent: Paragraph 0041-0043

2-AMINO-5-IODOBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-IODOBENZONITRILE Suppliers

China 72 Germany 1 India 3 United Kingdom 1 United States 6 Global 83

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View Lastest Price from 2-AMINO-5-IODOBENZONITRILE manufacturers

Career Henan Chemical Co

Product: 2-AMINO-5-IODOBENZONITRILE 132131-24-9
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-15

132131-24-9, 2-AMINO-5-IODOBENZONITRILERelated Search:

2,4-difluoro-5-hydroxybenzonitrile 2,3-DICHLORO-6-FLUOROBENZONITRILE 2,4-DIHYDROXYBENZONITRILE Benzonitrile, 2,5-difluoro-4-hydroxy- 2-AMINO-5-BROMO-3-FLUORO-BENZONITRILE 3,6-DICHLORO-2-FLUOROBENZONITRILE 2,5-Dibromo-3-fluorobenzonitrile 2-Amino-4,5-dichloro-benzonitrile Benzonitrile, 2-amino-3,6-difluoro- (9CI) 2,3-Dichloro-4-fluorobenzonitrile 3-BroMo-2,5-difluorobenzonitrile 2-aminobutanenitrile

2-AMINO-5-IODOBENZONITRILE

2-Cyano-4-iodoaniline

2-aminio-5-iodobenzonitrile

5-iodoanthranilonitrile

Benzonitrile, 2-amino-5-iodo-

132131-24-9

C7H5N2I