Benzyl vinylcarbamate
- Product Name
- Benzyl vinylcarbamate
- CAS No.
- 84713-20-2
- Chemical Name
- Benzyl vinylcarbamate
- Synonyms
- benzyl vinylcarbamate;N-Cbz-ethenamine;benzyl ethenylcarbamate;BENZYL-N-VINYLCARBAMATE;N-Vinyl-O-benzyl urethane;O-Benzyl-N-vinylcarbamate;benzyl N-ethenylcarbamate;Phenylmethyl ethenylcarbamate;Carbamic acid, N-ethenyl-, phenylmethyl ester
- CBNumber
- CB1679005
- Molecular Formula
- C10H11NO2
- Formula Weight
- 177.2
- MOL File
- 84713-20-2.mol
Benzyl vinylcarbamate Property
- Melting point:
- 43-44°C
- Boiling point:
- 272℃
- Density
- 1.089
- Flash point:
- 118℃
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 11.04±0.46(Predicted)
- color
- White to Off-White
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B316510
- Product name
- BenzylVinylcarbamate
- Packaging
- 2.5g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- FB141802
- Product name
- Benzyl Vinylcarbamate
- Packaging
- 2g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 3024AC
- Product name
- Benzylvinylcarbamate
- Packaging
- 2g
- Price
- $590
- Updated
- 2021/12/16
- Product number
- FB141802
- Product name
- Benzyl Vinylcarbamate
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB141802
- Product name
- Benzyl Vinylcarbamate
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
Benzyl vinylcarbamate Chemical Properties,Usage,Production
Uses
Benzyl Vinylcarbamate is used as a reagent in the synthesis of CF3- or -?CF2-?substituted tetrahydroquinolines.
Preparation
A 1-L flask was equipped with a variable speed pump, a mechanical stirrer, a temperature controller, a 4" (10 cm) column packed with ceramic saddles, a distillation head, a spiral condenser (cooled with water at 10–15 ℃), and a receiver. The flask was charged with toluene (150–200 mL) and phenothiazine (0.5 g) and the solution was heated to 105–110 ℃. The receiver was charged with benzyl alcohol (86 g, 0.8 mol), phenothiazine (0.05 g), and triethylamine (0.1–0.3 g). This mixture was cooled in ice and stirred. A solution of acryloyl azide (1 mol), prepared as described above, was pumped into the distillation flask over a period of 4–5 h, maintaining the pot temperature at 105–110 ℃ with a heating mantle. The vapor temperature varied, depending on the rate of addition of the azide, but was in the range 80–100 ℃. The distillate was passed directly into the benzyl alcohol mixture. After the addition of acryloyl azide, the distillation continued, generating a further 10–20 mL of toluene. The receiver was then removed from the distillation set-up, and its contents were stirred at 0–5 ℃ for 1– 2 h. The product mixture was then allowed to gradually warm to room temperature and was stirred until HPLC analysis indicated complete reaction. The mixture was then concentrated in vacuo to a weight of 200–250 g. The residue was treated with heptane (300–350 mL) and cooled to 15 ℃ with stirring. A few seed crystals of benzyl N-vinyl carbamate 810 were added, and the mixture was stirred for 2–3 h. The product was collected by filtration, washed with heptane, and dried in vacuo. Yield 115–128 g (65–72%); mp 41–44 ℃.
Application
Benzyl-N-vinyl carbamate (Z-vinylamine; Benzyl vinylcarbamate) is a valuable synthetic intermediate. This compound undergoes alkylation readily on the carbon R to the nitrogen, a property that has been used in the synthesis of a-lactam antibiotics. Z-vinylamine can be readily polymerized into polyvinyl amine derivatives[1].
Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 4649, 1989 DOI: 10.1021/jo00280a036
References
[1] Govindan, Cheruthur K. “An Improved Process for the Preparation of Benzyl-N-vinyl Carbamate1.” Organic Process Research Development 6 1 (2001): 74–77.
Benzyl vinylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
Benzyl vinylcarbamate Suppliers
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9513
- Advantage
- 66
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4940
- Advantage
- 60
- Tel
- 18151128828
- Fax
- -
- hc-sales@foxmail.com
- Country
- China
- ProdList
- 2602
- Advantage
- 55
- Tel
- +86 574 8729 6330
- Fax
- +86 574 8729 7461
- info@chemik.com
- Country
- China
- ProdList
- 3616
- Advantage
- 61
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10274
- Advantage
- 55
- Tel
- 028-85305008 02885305008
- Fax
- 4000210878-186
- 2306208234@qq.com
- Country
- China
- ProdList
- 1006
- Advantage
- 50
- Tel
- 0571-82896630 18969958410
- sales_hz@milestonepharmtech.com
- Country
- China
- ProdList
- 4853
- Advantage
- 55
- Tel
- 21-65679720
- Fax
- 0086-21-5186 1128
- service@speedchemical.com
- Country
- China
- ProdList
- 604
- Advantage
- 55
- Tel
- 13912302692 13912302692
- Fax
- 0519-88064678
- sales@anxuanchem.com
- Country
- China
- ProdList
- 4822
- Advantage
- 58
- Tel
- 023-63225655 13320248848
- Fax
- 023-63225655QQ2366581735
- 2366581735@qq.com
- Country
- China
- ProdList
- 510
- Advantage
- 55
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8012
- Advantage
- 62
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13761310616
- Fax
- QQ: 39324283
- 39324283@qq.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- 021-021-58950110 13124863828
- Fax
- 021-20922272
- sales@linkchem.cn
- Country
- China
- ProdList
- 2981
- Advantage
- 58
- Tel
- +86-（0）57185586718 +86-13336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29791
- Advantage
- 60
- Tel
- 025-66028182 18112977050
- Fax
- (3)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 15818
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 15497
- Advantage
- 58
- Tel
- 18367600069
- Fax
- QQ3388371646
- pinghushizy@163.com
- Country
- China
- ProdList
- 7803
- Advantage
- 58
- Tel
- 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 13010
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8613367258412
- Fax
- 18062427325
- ada@ipurechemical.com
- Country
- China
- ProdList
- 10319
- Advantage
- 58
- Tel
- 86 18062405514 18062405514
- ada@ipurechemical.com
- Country
- CHINA
- ProdList
- 3461
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30239
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 10003
- Advantage
- 58
- Tel
- 0510-0510-86838766
- 2258830676@qq.com
- Country
- China
- ProdList
- 4584
- Advantage
- 58
- Tel
- 13674959855
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 3051
- Advantage
- 58
- Tel
- 18918399319 18918399319
- 24907461@qq.com
- Country
- China
- ProdList
- 253
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 11725
- Advantage
- 58
- Tel
- 021-54721350 13524668266
- Fax
- 021-5
- 2881505714@qq.com
- Country
- China
- ProdList
- 7872
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- 650-6922368
- sales@achemblock.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7977
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8617
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44458
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 39995
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 6887
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62075
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 0574-27891269 18667892864
- frank.xiaodong@chemriotech.com
- Country
- China
- ProdList
- 3722
- Advantage
- 58
- Tel
- 2122619822
- czbjpharma@126.com
- Country
- China
- ProdList
- 18478
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9956
- Advantage
- 58
- Tel
- 400-8675577 19945755304
- sales@chemany.com
- Country
- China
- ProdList
- 9943
- Advantage
- 58
- Tel
- 17347485752 19526192903
- 610451109@qq.com
- Country
- China
- ProdList
- 178
- Advantage
- 58
- Tel
- 0573-85609002 18157336032
- zhejia01@163.com
- Country
- China
- ProdList
- 7859
- Advantage
- 58
- Tel
- 18072846723; 18072846723
- caigou1@witofly.com
- Country
- China
- ProdList
- 3071
- Advantage
- 58
- Tel
- 19719236623
- 2885515945@qq.com
- Country
- China
- ProdList
- 1474
- Advantage
- 58
- Tel
- 18782236258; 18782236258
- 3541769756@qq.com
- Country
- China
- ProdList
- 168
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 021-57520305 15221441005
- wangkang@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58