4-BENZO[1,3]DIOXOL-5-YL-THIAZOL-2-YLAMINE
- Product Name
- 4-BENZO[1,3]DIOXOL-5-YL-THIAZOL-2-YLAMINE
- CAS No.
- 185613-91-6
- Chemical Name
- 4-BENZO[1,3]DIOXOL-5-YL-THIAZOL-2-YLAMINE
- Synonyms
- Octanoicacid,10-mercapto-;5-(2-AMINO-4-THIAZOLYL)-1,3-BENZODIOXOLE;4-BENZO[1,3]DIOXOL-5-YL-THIAZOL-2-YLAMINE;2-Thiazolamine, 4-(1,3-benzodioxol-5-yl)-;4-(benzo[d][1,3]dioxol-5-yl)thiazol-2-amine;4-(1,3-BENZODIOXOL-5-YL)-1,3-THIAZOL-2-AMINE;4-(1,3-BENZODIOXOL-5-YL)-1,3-THIAZOL-2-YLAMINE;4-(2H-1,3-Benzodioxol-5-yl)-1,3-thiazol-2-amine
- CBNumber
- CB1685459
- Molecular Formula
- C10H8N2O2S
- Formula Weight
- 220.25
- MOL File
- Mol file
4-BENZO[1,3]DIOXOL-5-YL-THIAZOL-2-YLAMINE Property
- Boiling point:
- 427.8±34.0 °C(Predicted)
- Density
- 1.459±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.27±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B200085
- Product name
- 4-Benzo[1,3]dioxol-5-yl-thiazol-2-yl-amine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B200085
- Product name
- 4-Benzo[1,3]dioxol-5-yl-thiazol-2-yl-amine
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- HTS028147
- Product name
- 4-(1,3-benzodioxol-5-yl)-1,3-thiazol-2-amine
- Packaging
- 20mg
- Price
- $267
- Updated
- 2021/12/16
- Product number
- 033385
- Product name
- 4-Benzo[1,3]dioxol-5-yl-thiazol-2-ylaminehydrobromide
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- CHM0121519
- Product name
- 4-(1,3-BENZODIOXOL-5-YL)-1,3-THIAZOL-2-YLAMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
4-BENZO[1,3]DIOXOL-5-YL-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production
Synthesis
40288-65-1
17356-08-0
185613-91-6
General procedure for the synthesis of 4-(benzo[d][1,3]dioxol-5-yl)thiazol-2-amine from 1-(benzo[d][1,3]dioxol-5-yl)-2-bromoacetophenone (3.00 g, 12.3 mmol) and thiourea (1.88 g, 24.7 mmol): 1-(benzo[d][1,3]dioxol-5-yl)-2-bromoethanone was dissolved in ethanol (150 ml) followed by addition of thiourea. -yl)-2-bromoacetophenone was dissolved in ethanol (150 ml) followed by addition of thiourea. The reaction mixture was heated to 66-80°C under nitrogen protection and stirred for 24 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate and washed with saturated NaHCO3 solution. The organic layer was separated, dried with anhydrous Na2SO4, filtered and purified by column chromatography (eluent ratio THF:hexane=1:3). The yield of the final product was 41.3%.
References
[1] Patent: KR101651208, 2016, B1. Location in patent: Paragraph 0127-0129
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 21, p. 4854 - 4857
4-BENZO[1,3]DIOXOL-5-YL-THIAZOL-2-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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