OMAPATRILAT

Product Name: OMAPATRILAT
CAS No.: 167305-00-2
Chemical Name: OMAPATRILAT
Synonyms: VANLEV;OMAPATRILAT;BMS 186716-01;OMAPATRILAT/VANLEV;Omapatrilat (BMS-186716);Omapatrilat >=98% (HPLC);7H-Pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-, (4S,7S,10aS)-
CBNumber: CB1695018
Molecular Formula: C19H24N2O4S2
Formula Weight: 408.53
MOL File: 167305-00-2.mol

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OMAPATRILAT Property

Melting point:: 218-220°
alpha: D -78.9° (c = 0.46 in DMF)
Boiling point:: 724.2±60.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 30 mg/ml
form: A crystalline solid
pka: 3.44±0.40(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6369
Product name: Omapatrilat
Purity: >97.0%
Packaging: 10mg
Price: $156
Updated: 2021/12/16

ChemScene

Product number: CS-6369
Product name: Omapatrilat
Purity: >97.0%
Packaging: 25mg
Price: $336
Updated: 2021/12/16

ChemScene

Product number: CS-6369
Product name: Omapatrilat
Purity: >97.0%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009247
Product name: OMAPATRILAT
Purity: 95.00%
Packaging: 5MG
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-6369
Product name: Omapatrilat
Purity: >97.0%
Packaging: 50mg
Price: $624
Updated: 2021/12/16

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OMAPATRILAT Chemical Properties,Usage,Production

Uses

Treatment of hypertension and congestive heart failure (neutral endopeptidase and angiotensin converting enzyme inhibitor).

Definition

ChEBI: Omapatrilat is a dipeptide.

in vivo

Omapatrilat demonstrates excellent blood pressure lowering in a variety of animal models characterized by various levels of plasma renin activity and significantly potentiates urinary sodium, ANP, and cGMP excretion in a cynomolgus monkey assay. Omapatrilat decreases mean arterial pressure (MAP) approximately 40 mmHg below baseline from 10 to 24 h. Oral administration of omapatrilat at 100 μM/kg once daily results in a 38 mmHg decrease in systolic blood pressure at day three as compared to vehicle ^[2]. Omapatrilat is widely used in experimental protocols related to hypertension and heart failure. Chronic oral administration of omapatrilat reduces aortic leakiness and atheroma formation with enhanced endothelial independent vasorelaxation to ANP^[3]. Omapatrilat causes significant inhibition of plasma ACE and increased plasma renin activity in rats^[4].

OMAPATRILAT Preparation Products And Raw materials

Raw materials

Preparation Products

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OMAPATRILAT Suppliers

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167305-00-2, OMAPATRILATRelated Search:

CHEMBRDG-BB 4015189 1-ETHYL-PIPERIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE AKOS BC-0095 CHEMBRDG-BB 4011096 2-(dibutylamino)acetic acid 1-ACETYL-2-PIPERIDINECARBOXYLIC ACID OMAPATRILAT

OMAPATRILAT

VANLEV

OMAPATRILAT/VANLEV

BMS 186716-01

7H-Pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-, (4S,7S,10aS)-

Omapatrilat >=98% (HPLC)

Omapatrilat (BMS-186716)

167305-00-2

16730-00-2