4-Methoxy-3-nitropyridine
- Product Name
- 4-Methoxy-3-nitropyridine
- CAS No.
- 31872-62-5
- Chemical Name
- 4-Methoxy-3-nitropyridine
- Synonyms
- CBI-BB ZERO/004611;4-Metho×y-3-nitropyridine;3-Nitro-4-Methoxypyridine;4-METHOXY-3-NITROPYRIDINE;Pyridine,4-methoxy-3-nitro-;4-Methoxy-3-nitropyridine>4-Methoxy-3-nitropyridine ,98%;Methyl 3-nitro-4-pyridinyl ether;4-Methoxy-3-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB1700338
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 31872-62-5.mol
4-Methoxy-3-nitropyridine Property
- Melting point:
- 74.0 to 78.0 °C
- Boiling point:
- 127°C/1mmHg(lit.)
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 2.51±0.18(Predicted)
- color
- Pale Yellow
- InChIKey
- BZPVREXVOZITPF-UHFFFAOYSA-N
- CAS DataBase Reference
- 31872-62-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-22
- Safety Statements
- 26-36/37/39-36-37
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 734209
- Product name
- 4-Methoxy-3-nitropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $64.2
- Updated
- 2023/06/20
- Product number
- 734209
- Product name
- 4-Methoxy-3-nitropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $237
- Updated
- 2022/05/15
- Product number
- M2283
- Product name
- 4-Methoxy-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- M2283
- Product name
- 4-Methoxy-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $244
- Updated
- 2025/07/31
- Product number
- M3256-35
- Product name
- 4-Methoxy-3-nitropyridine
- Packaging
- 1g
- Price
- $312
- Updated
- 2021/12/16
4-Methoxy-3-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
4-Methoxy-3-nitropyridine is a useful synthetic intermediate.
Synthesis
620-08-6
31872-62-5
The general procedure for the synthesis of 4-methoxy-3-nitropyridine from 4-methoxypyridine was as follows: 4-methoxypyridine (0.5 mL, 4.9 mmol) was slowly added dropwise to concentrated sulfuric acid (5 mL) cooled in an ice bath, and the dropwise time was controlled to be within 20 seconds. Subsequently, fuming nitric acid (5 mL) was added to the reaction mixture and the mixture was heated and reacted at 70 °C for 2.5 days. After completion of the reaction, the mixture was cooled to room temperature and then carefully poured into ice water. The pH of the mixture was adjusted to alkaline with solid potassium carbonate (K2CO3). The mixture was partitioned between water (H2O) and ethyl acetate (EtOAc) to separate the organic and aqueous layers. The aqueous layer was extracted once more with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, and then dried over anhydrous magnesium sulfate (MgSO4). The dried organic phase was filtered and concentrated in vacuum to give a yellow powdery product 4-methoxy-3-nitropyridine 0.7 g in 92% yield. The structure of the product was confirmed by 1H NMR (CDCl3, 300 MHz) and LC-MS: 1H NMR δ 9.02 (s, 1H), 8.65 (d, J = 5.8 Hz, 1H), 7.04 (d, J = 5.9 Hz, 1H), 4.05 (s, 3H); LC-MS m/z 155 (M + 1, 100%), retention time ( Rt) 0.5 min.
References
[1] Patent: WO2011/78984, 2011, A1. Location in patent: Page/Page column 62
4-Methoxy-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Methoxy-3-nitropyridine manufacturers
- Product
- 4-Methoxy-3-nitropyridine 31872-62-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-07
- Product
- Methyl 3-nitro-4-pyridinyl ether 31872-62-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24