ChemicalBook > CAS DataBase List > Erythromycin ethylsuccinate

Erythromycin ethylsuccinate

Product Name
Erythromycin ethylsuccinate
CAS No.
1264-62-6
Chemical Name
Erythromycin ethylsuccinate
Synonyms
Esinol;Evesin;Refkas;Anamycin;Arpimycin;E-Mycin e;Eryliquid;Monomycin;Sigapedil;Wyamycin E
CBNumber
CB1701234
Molecular Formula
C43H75NO16
Formula Weight
862.05
MOL File
1264-62-6.mol
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Erythromycin ethylsuccinate Property

Melting point:
219-224 C
Boiling point:
778.19°C (rough estimate)
Density 
1.1417 (rough estimate)
refractive index 
1.5280 (estimate)
Flash point:
>110°(230°F)
storage temp. 
Sealed in dry,Room Temperature
solubility 
ethanol: soluble50mg/mL
form 
solid
pka
13.09±0.70(Predicted)
color 
white
Water Solubility 
Freely soluble in organic solvents, practically insoluble in water
Stability:
Hygroscopic
InChIKey
NSYZCCDSJNWWJL-UHFFFAOYSA-N
SMILES
C1(OC(=O)CCC(OCC)=O)C(N(C)C)CC(C)OC1OC1C(CC(C(C(C(O)C(O)(C)C(CC)OC(=O)C(C)C(OC2OC(C)C(O)C(C)(OC)C2)C1C)C)=O)C)(O)C
CAS DataBase Reference
1264-62-6
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
42/43-36/37/38
Safety Statements 
36-26
WGK Germany 
2
RTECS 
WM9800000
HS Code 
29419000
Hazardous Substances Data
1264-62-6(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: > 10gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001845
Product name
Erythromycin ethylsuccinate for impurity P identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$235
Updated
2025/07/31
Sigma-Aldrich
Product number
E1500000
Product name
Erythromycin ethyl succinate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10 mg
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
1245008
Product name
Erythromycin ethyl succinate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$374
Updated
2025/07/31
Sigma-Aldrich
Product number
E8755
Product name
Erythromycin ethyl succinate
Packaging
5g
Price
$84.5
Updated
2023/06/20
Sigma-Aldrich
Product number
PHR1610
Product name
Erythromycin ethyl succinate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
250mg
Price
$113
Updated
2025/07/31
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Erythromycin ethylsuccinate Chemical Properties,Usage,Production

Chemical Properties

Erythromycin ethylsuccinate is a white powder or crystals, odourless and tasteless. It is insoluble in water, slightly soluble in diethyl ether, and readily soluble in anhydrous ethanol, acetone or chloroform.

Uses

A broad spectrum antibiotic commonly targeting bacteria responsible for respiratory tract infections

Definition

ChEBI: Erythromycin ethylsuccinate is a erythromycin derivative that is erythromycin A in which the hydroxy group at position 3R is substituted by a (4-ethoxy-4-oxobutanoyl)oxy group. It is used for the treatment of a wide variety of bacterial infections. It is a succinate ester, a cyclic ketone, an erythromycin derivative and an ethyl ester. It is functionally related to an erythromycin A.

Application

Erythromycin Ethylsuccinate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[1][2][3] by various chromatography techniques.

brand name

E-Mycin (Pharmacia & Upjohn); E.E.S. (Abbott); Eryped (Abbott); Pediamycin (Ross); Wyamycin (Wyeth).

General Description

Erythromycin ethylsuccinate (EES, Pediamycin, EryPed) isthe ethylsuccinate mixed ester of erythromycin in which the2＇-hydroxyl group of the desosamine is esterified. It isabsorbed as the ester and hydrolyzed slowly in the body toform erythromycin. It is somewhat acid labile, and itsabsorption is enhanced by the presence of food. The ester isinsoluble in water but soluble in alcohol and ether.

References

[1] FAHIMEH KAMAREI . Development of a stability-indicating high performance liquid chromatography method for assay of erythromycin ethylsuccinate in powder for oral suspension dosage form[J]. Arabian Journal of Chemistry, 2014, 7 6: Pages 1079-1085. DOI:10.1016/j.arabjc.2011.01.004. 
[2] B. LIAWRUANGRATH   S. L. High performance thin layer chromatographic determination of erythromycin in pharmaceutical preparations[J]. Chromatographia, 2001, 54 5-6: 405-408. DOI:10.1007/BF02492693. 
[3] JACQUELINE WARDROP . Determination of Erythromycin and Related Substances in Enteric‐Coated Tablet Formulations by Reversed‐Phase Liquid Chromatography[J]. Journal of pharmaceutical sciences, 2000, 89 9: Pages 1097-1105. DOI:10.1002/1520-6017(200009)89:9<1097::AID-JPS1>3.0.CO;2-D.

Erythromycin ethylsuccinate Preparation Products And Raw materials

Raw materials

Succinic anhydride Tetrahydrofuran Erythromycin

Preparation Products

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Erythromycin ethylsuccinate Suppliers

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View Lastest Price from Erythromycin ethylsuccinate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Erythromycin ethylsuccinate 1264-62-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
USP40
Supply Ability
8000kg/month
Release date
2021-06-10
Hebei Chuanghai Biotechnology Co., Ltd
Product
Erythromycin ethylsuccinate 1264-62-6
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Erythromycin Ethylsuccinate 1264-62-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-04-02

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  • (2S,3R,4S,6R)-4-(Dimethylamino)-2-(((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecan-6-yl)oxy)-6-methyltetrahydro-2H-pyran-3-yl ethyl succinate
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