Tetracycline hydrochloride

ChemicalBook > CAS DataBase List > Tetracycline hydrochloride

Tetracycline hydrochloride

Chemistry Indication Mode of action Pharmacodynamic Resistance issue Side effects

Product Name: Tetracycline hydrochloride
CAS No.: 64-75-5
Chemical Name: Tetracycline hydrochloride
Synonyms: TETRACYCLINE HCL;sumycin;cyclopar;tetrachel;topicycline;cancycline-250;Tetracyclin HCl;amycin,hydrochloride;ACHROMYCIN HYDROCHLORIDE;alatet
CBNumber: CB1704886
Molecular Formula: C22H25ClN2O8
Formula Weight: 480.9
MOL File: 64-75-5.mol

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Tetracycline hydrochloride Property

Melting point:: 220-223 °C(lit.)
alpha: -252 º (c=0.5, H2O)
refractive index: -253 ° (C=0.5, 0.1mol/L HCl)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: H₂O: 10 mg/mL as a stock solution. Stock solutions should be filtered sterilized and stored at −20°C. Stable at 37°C for 4 days.
form: powder
color: faint yellow to yellow
PH: pH(10g/l, 25℃) : 1.8～3.0
optical activity: [α]/D -255 to 240° (Specific rotation )
Water Solubility: 50 g/L
Sensitive: Air & Light Sensitive
Merck: 14,9196
BRN: 3844873
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: XMEVHPAGJVLHIG-FMZCEJRJSA-N
CAS DataBase Reference: 64-75-5(CAS DataBase Reference)
EPA Substance Registry System: Tetracycline hydrochloride (64-75-5)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36
RIDADR: UN 3077 9 / PGIII
WGK Germany: 2
RTECS: QI9100000
F: 8-10-23
TSCA: Yes
HazardClass: 3
HS Code: 29413000
Toxicity: LD50 orally in rats: 6443 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 31741
Product name: Tetracycline hydrochloride
Purity: VETRANAL
Packaging: 250mg
Price: $60.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1651009
Product name: Tetracycline hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: T0600000
Product name: Tetracycline hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: T0600000
Price: $212
Updated: 2023/06/20

Sigma-Aldrich

Product number: 58346-M
Product name: Tetracycline, Hydrochloride - CAS 64-75-5 - Calbiochem
Packaging: 10g
Price: $54.5
Updated: 2023/01/07

Sigma-Aldrich

Product number: 58346-M
Product name: Tetracycline, Hydrochloride - CAS 64-75-5 - Calbiochem
Packaging: 25g
Price: $63.8
Updated: 2022/05/15

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Tetracycline hydrochloride Chemical Properties,Usage,Production

Chemistry

Tetracyclines and analogues with biological effects on bacteria and mammalian targets show a basic chemical structure consisting of a tetracyclic naphthacene carboxamide ring system (Fig 1). Tetracyclines with antibiotic activity have a dimethylamine group at carbon 4 (C4) in ring A. Removal of the dimethylamino group from C4 reduces its antibiotic properties, but enhances non-antibiotic actions^[3]. Utilization of this strategy was the basis for the development of several chemically modified tetracyclines^[2]. The ring structure of tetracyclines is surrounded by upper and lower peripheral zones. These contain various chemical functional groups and substituents^[12]. Synthetic modification of the lower peripheral region reduces both antibiotic and non-antibiotic properties. On the other hand, biological targets may be enhanced by modifying the upper peripheral zone, particularly in positions C7 through C9 of the D ring. This has been accomplished with tetracycline semisynthetic compounds such as minocycline and doxycycline^[3].

Indication

Tetracyline hydrochloride is used for the treatment of bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsia pox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.

Mode of action

The tetracyclines inhibit bacterial growth primarily by inhibiting protein synthesis at the level of the ribosome^[13-16]. Inhibition of protein synthesis results from disruption of codon-anticodon interactions between tRNA and mRNA so that binding of aminoacyl-tRNA to the ribosomal acceptor (A) site is prevented^{[14, 15]}. The precise mechanism by which tetracyclines prevent attachment of aminoacyl-tRNA to the A site is not understood. However, inhibition is likely to result from interaction of these antibiotics with the 30S ribosomal subunit since many of the tetracyclines are known to bind strongly to a single site on the 30S subunit^[15]. Nevertheless, interaction of these tetracyclines with the 30S ribosomal subunit is reversible since these agents are bacteriostatic.

Pharmacodynamic

Absorption is variable ranging from 0% to almost 90%; however, for most agents it is in the range 25–60%^[17]. Serum concentrations rise slowly after oral administration with absorption occurring in the stomach, duodenum and small intestine. Cmax (mg/L) depends on dose, but is generally in the range 1–5 mg/L. Tmax is in the range 2–4 h. All these tetracyclines form insoluble complexes with calcium, magnesium, iron and aluminium, which markedly reduce absorption[18]. the effect of disease on the absorption of these drugs is unknown. Protein, fat and carbohydrate meals reduce the absorption of tetracycline by about 50%^[16]. The volume of distribution (V) for these agents is in the order of 1.3–1.7 L/kg or a total volume of distribution of 100–130 L. These data imply some concentration in tissues; however, most data on tissue penetration are of poor quality, making firm conclusions about their relative distribution difficult. Protein binding is variable. None of these agents undergoes metabolism with the exception of tetracycline, 5% of which is excreted as the metabolite D-epitetracycline. Unchanged drugs are excreted by renal and bilary routes. Renal elimination (CLR) is related to glomerular filtration for most agents, the exception being chlortetracycline.^{[19, 20]} The amount of drug excreted in the urine is <50%; rolitetracycline is said to have high renal elimination. Greater than 40% appears in the faeces after biliary elimination and most drugs have some enterohepatic circulation.^{[18, 22]}

Resistance issue

Bacterial resistance to clinically useful tetracyciines is predominantly due to acquired resistance i.e. when resistant strains emerge from previously sensitive bacterial populations by acquisition of resistant genes. In essence, this results from the selective pressure exerted on bacteria during the administration of tetracyciines for chemotherapy in humans and animals. The genes determining resistance to tetracyciines usually reside in plasmids and/or transposons^{[11, 15]}. It is now well recognized that acquisition of resistance determinants on plasmids and transposons is particularly important in the evolution of antibiotic resistant bacteria because it provides the recipient cell with pre-evolved genes refined to express high-level resistance^[23].
Three distinct biochemical mechanisms of resistance to tetracyciines have been identified: (a) energy-dependent efflux of antibiotic mediated by resistance proteins that are inserted into the bacterial cytoplasmic membrane^{[15, 24, 25]}; (b) ribosomal protection whereby tetracyciines no longer bind productively to the bacterial ribosome^{[25, 26]}, and (c) chemical alteration of the tetracycline molecule by a reaction that requires oxygen and which renders the drug inactive as an inhibitor of protein synthesis^[25].

Side effects

The ability of tetracyclines to cause permanent discolouration of teeth is well-known and therefore these antibiotics are not administered to children less than eight years old. Tetracyclines are also contra-indicated in children because they can cause temporary inhibition of bone growth. Tetracyclines can produce Candida! Overgrowth or diarrhoea due to the relatively high proportion of antibiotic reaches the lower gastrointestinal tract. These antibiotics tend to accumulate in patients with renal insufficiency and may cause further impairment of renal function including nephrotoxicity and/or nephrogenic diabetes insipidus. Phototoxic reactions occasionally occur with tetracycline and minocycline, but are less common with doxycycline. Rarely, tetracyclines may cause benign intracranial hypertension, presenting as blurring of vision and headache often in young adults who are being treated for acne^[27]. Minocycline can cause vestibular disturbance. Amongst the tetracyclines this effect is apparently unique to minocycline and probably relates to the high lipid solubility of the drug. The lipid-laden cells of the vestibular apparatus are believed to concentrate the drug resulting in vertigo and nausea. However, the effects are reversible upon discontinuation of therapy with the antibiotic.

Description

Tetracycline is a broad-spectrum antibiotic that prevents bacterial growth by inhibiting protein synthesis. It binds to a single site in the 30S ribosomal subunit which prevents attachment of aminoacyl tRNA to the ribosomal acceptor site. It is used in cell biology as a selective agent in cell culture systems. Tetracycline is toxic to prokaryotic and eukaryotic cells and selects for cells harboring the bacterial tetR gene, which are resistant to the antibiotic.

Chemical Properties

Yellow crystalline powder

Uses

Antibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial.

Uses

Tetracycline hydrochloride is used to induce apoptosis in osteoclasts. It is used to treat acne and other skin infections, respiratory tract infections like pneumonia, genital, urinary infections, leptospirosis, helicobacter pylori, taxoplasmosis, mycoplasma, psittacosis for dog and cats. It also works more effectively in animals that have tick-borne infections. It is also useful in cell culture applications.

Uses

Tetracycline hydrochloride is a salt prepared from tetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Tetracycline hydrochloride has broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-unit,s blocking protein synthesis.

General Description

Crystals or fine bright yellow powder. pH of 2% aqueous solution: 2.1 - 2.3.

Air & Water Reactions

Water soluble.

Reactivity Profile

Tetracycline hydrochloride is acidic. Reacts with strong oxidizing agents .

Fire Hazard

Flash point data concerning Tetracycline hydrochloride are not available, however, Tetracycline hydrochloride is probably combustible.

Biochem/physiol Actions

Primary Targetbinding of aminoacyl tRNA to the A-site of ribosomes

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects: change in taste function. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also TETRACYCLINE.

Veterinary Drugs and Treatments

While tetracycline still is used as an antimicrobial, most small animal clinicians prefer doxycycline and large animal clinicians prefer oxytetracycline when a tetracycline is indicated to treat susceptible infections. The most common use of tetracycline HCl today is in combination with niacinamide for the treatment of certain immune- mediated skin conditions in dogs, such as pemphigus.

Purification Methods

The hydrochloride is recrystallised from MeOH/n-BuOH or n-BuOH/HCl. It is insoluble in Et2O and pet ether. It has UV max at 270 and 366nm in MeOH. [Gottstein et al. J Am Chem Soc 81 1198 1959, Conover et al. J Am Chem Soc 84 3222 1962, Stephen et al. J Am Chem Soc 78 4155 1956, Beilstein 14 IV 2627.]

Tetracycline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tetracycline hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tetracycline hydrochloride 64-75-5
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 95%-102%; EP9/BP2015
Supply Ability: 10 tons
Release date: 2021-07-08

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Tetracycline hydrochloride 64-75-5
Price: US $0.00/kg
Min. Order: 25kg
Purity: 95%-102%
Supply Ability: 10tons
Release date: 2024-04-24

Apeloa production Co.,Limited

Product: Tetracycline hydrochloride 64-75-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 30000
Release date: 2024-06-04

64-75-5, Tetracycline hydrochlorideRelated Search:

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TETRACYCLIN HYDROCHLORIDE VETRANAL, 250 MG