NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
- Product Name
- NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
- CAS No.
- 220805-22-1
- Chemical Name
- NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
- Synonyms
- ADMA;ADMA 2HCL;ADMA DIHYDROCHLORIDE;asym-Dimethylarginine;asym-Dimethylarginine, ADMA;Arginine Impurity 12 Dihydrochloride;NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE;NG,NG-dimethyl-L-Arginine (hydrochloride);NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE;NG,NG-Dimethylarginine Dihydrochloride，ADMA
- CBNumber
- CB1706734
- Molecular Formula
- C8H20Cl2N4O2
- Formula Weight
- 275.18
- MOL File
- 220805-22-1.mol
NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Property
- Melting point:
- 202-204OC
- storage temp.
- room temp
- solubility
- DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
- form
- White to off-white crystalline solid.
- color
- White to Off-White
- Water Solubility
- Soluble in water (100 mM)
- Stability:
- Store at 0-5°C; Moisture Sensitive; Hygroscopic
- CAS DataBase Reference
- 220805-22-1
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- D4268
- Product name
- NG,NG-Dimethylarginine dihydrochloride
- Packaging
- 10mg
- Price
- $80.7
- Updated
- 2024/03/01
- Product number
- D4268
- Product name
- NG,NG-Dimethylarginine dihydrochloride
- Packaging
- 50mg
- Price
- $281
- Updated
- 2024/03/01
- Product number
- 311203
- Product name
- NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem
- Purity
- A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC?? = 2-3 μM) and in vivo.
- Packaging
- 25MG
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 80230
- Product name
- NG,NG-dimethyl-L-Arginine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 80230
- Product name
- NG,NG-dimethyl-L-Arginine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $45
- Updated
- 2024/03/01
NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
Uses
NG,NG- Dimethylarginine dihydrochloride has been used:
- to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
- as a standard for measuring L-arginine and dimethylarginines
- to study its effects on hepatic deterioration
General Description
NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).
Biological Activity
ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence.
Biochem/physiol Actions
Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.
in vitro
ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1].
in vivo
animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
storage
Room temperature (desiccate)
References
[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992).