Paroxetine maleate

Product Name: Paroxetine maleate
CAS No.: 64006-44-6
Chemical Name: Paroxetine maleate
Synonyms: gf74;FG-7051;BRL-29060;fg7051maleate;PAROXETINE MALEATE;,(z)-2-butenedioate;ZoxaMide Impurity 2;Paroxetine maleate salt;Paroxetine maleate solution;3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-3-((trans-(-)-piperidin
CBNumber: CB1712562
Molecular Formula: C23H24FNO7
Formula Weight: 445.44
MOL File: 64006-44-6.mol

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Paroxetine maleate Property

Melting point:: 136-138°C
alpha: D -87° (c = 5 in ethanol)
Flash point:: 9℃
storage temp.: 2-8°C
solubility: DMSO: ~12 mg/mL
form: solid
color: white

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 26-36-45-36/37-16-7
RIDADR: 3249
WGK Germany: 3
RTECS: TM4569300
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P-916
Product name: Paroxetine maleate solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $38.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1372
Product name: Paroxetine maleate salt
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1372
Product name: Paroxetine maleate salt
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $637
Updated: 2024/03/01

Tocris

Product number: 2141
Product name: Paroxetinemaleate
Purity: ≥99%(HPLC)
Packaging: 50
Price: $616
Updated: 2021/12/16

Tocris

Product number: 2141
Product name: Paroxetinemaleate
Purity: ≥99%(HPLC)
Packaging: 10
Price: $151
Updated: 2021/12/16

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Paroxetine maleate Chemical Properties,Usage,Production

Uses

Paroxetine maleate is a selective serotonin uptake inhibitor.

Definition

ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2

General Description

Paroxetine, marketed under trade names such as Paxil^? or Aropax, is an SSRI antidepressant used to treat many conditions in adults from major depression and obsessive-compulsive disorder to several anxiety disorders. Suitable uses for this certified solution standard include as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications such as urine drug testing, prescription monitoring, clinical toxicology, or forensic analysis.

Biological Activity

Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo .

Biochem/physiol Actions

Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.

storage

Store at RT

Paroxetine maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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Paroxetine maleate Suppliers

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64006-44-6, Paroxetine maleateRelated Search:

Dimethyldimethoxysilane Methyltriethoxysilane Methyl cellulose Bensulfuron methyl Methylparaben Enalapril maleate Paroxetine hydrochloride Triacetonediamine 4-Methoxyphenylacetone 2,2,6,6-Tetramethyl-4-piperidinol Bis(2-ethylhexyl) maleate Methyltrimethoxysilane Paroxetine METSULFURON METHYL Diphenyldimethoxysilane Kresoxim-methyl Methyl acrylate Methyl

BRL-29060

FG-7051

(3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE MALEATE

(3S,4R)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)-PIPERIDINE MALEATE

(-)-alpha-4-(4-fluorophenyl)-3-(1,3-benzdioxolyl-(3))-oxymethylpiperidinema

,(z)-2-butenedioate

3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-3-((trans-(-)-piperidin

PAROXETINE MALEATE

fg7051maleate

gf74

trans-(-)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidinem

BRL-29060, FG-7051, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate

(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt

Paroxetine maleate salt

Paroxetine maleate solution

Paroxetine maleate salt,(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt, BRL-29060, FG-7051

ZoxaMide Impurity 2

64006-44-6

C23H24FNO7

C19H20FNO3C4H4O4

C19H20NO3FC4H4O4

C19H20FNO7C4H4O4