ATPA

Product Name: ATPA
CAS No.: 140158-50-5
Chemical Name: ATPA
Synonyms: ATPA;(R,S)-ATPA;ATP synthase α chain;alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate;(RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID;2-Amino-3-(5-(tert-butyl)-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid;4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-
CBNumber: CB1719521
Molecular Formula: C10H16N2O4
Formula Weight: 228.25
MOL File: 140158-50-5.mol

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ATPA Property

Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: DMSO: 10 mg/mL
form: solid
pka: 2.15±0.10(Predicted)
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1107
Product name: ATPA
Purity: ≥98%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

Tocris

Product number: 1107
Product name: ATPA
Purity: ≥98%(HPLC)
Packaging: 50
Price: $936
Updated: 2021/12/16

Usbiological

Product number: 254690
Product name: ATPA
Packaging: 10mg
Price: $480
Updated: 2021/12/16

TRC

Product number: A790535
Product name: (R,S)-ATPA
Packaging: 1mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0021056
Product name: ATPA
Purity: >98.0%
Packaging: 10mg
Price: $685
Updated: 2021/12/16

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ATPA Chemical Properties,Usage,Production

Uses

(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.

Definition

ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid.

Biological Activity

A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .

storage

Desiccate at +4°C

ATPA Preparation Products And Raw materials

Raw materials

Preparation Products

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ATPA Suppliers

China 13 Germany 1 Switzerland 3 United Kingdom 1 United States 13 Global 31

AXXORA, LLC

Tel: --
Fax: --
Email: alexis-ch@alexis-corp.com
Country: Switzerland
ProdList: 1104
Advantage: 80

Alexis Corporation

Tel: --
Fax: --
Email: alexis-ch@alexis-corp.ch
Country: Switzerland
ProdList: 3599
Advantage: 74

SIGMA-RBI

Tel: --
Fax: --
Country: Switzerland
ProdList: 6896
Advantage: 91

140158-50-5, ATPARelated Search:

ATPA ( Z )-2-(2-AMINOTHIAZOL-4-YL)-2-PENTENOIC ACID (ATPA) ATPA ((RS)-2-AMINO-3-(3-HYDROXY-5-TERT-B,(R,S)-ATPA,ATPA (R)-ATPA, >97% (RS)-AMPA CHEMBRDG-BB 4009738 (R,S)-2-AMINO-3-[5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL]PROPIONIC ACID 2-ISOXAZOL-4-YL-ETHYLAMINE ATPA (R)-ATPA (S)-ATPA

(R,S)-ATPA

(RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID

(R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID

(RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID

(RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID

ATPA

alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate

ATP synthase α chain

4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-

2-Amino-3-(5-(tert-butyl)-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid

4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-

140158-50-5

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Ligand-Gated Ion Channels

Ion Channels

Ionotropic Glutamate Receptor Modulators