ChemicalBook > CAS DataBase List > PGP-4008

PGP-4008

Product Name
PGP-4008
CAS No.
365565-02-2
Chemical Name
PGP-4008
Synonyms
Abcb1b;PGP-4408;PGP-4008;Mdr1b Rat;PGP4008,PGP 4008;Mdr1b Rat Vesicular Transport Kit;PGP 4008, P-glycoprotein inhibitor;rodent multidrug resistance protein;Recombinant Human p-Glycoprotein/MRP;N-(1-BENZYL-2,3-DIHYDRO-1H-PYRROLO[2,3-B]QUINOLIN-4-YL)-2-PHENYLACETAMIDE
CBNumber
CB1722686
Molecular Formula
C26H23N3O
Formula Weight
393.48
MOL File
Mol file
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PGP-4008 Property

storage temp. 
−20°C
solubility 
DMSO: 50mM; Ethanol: 5mM
form 
White to off-white powder.
color 
White to off-white
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Safety

Hazard Codes 
T
Risk Statements 
45-21/22-34-37-52/53
Safety Statements 
22-24/25-61-45-36/37/39-26-53
WGK Germany 
3
HS Code 
3504009000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P6490
Product name
PGP-4008
Packaging
2MG
Price
$378
Updated
2022/05/15
Cayman Chemical
Product number
20901
Product name
PGP-4008
Purity
≥95%
Packaging
500μg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
20901
Product name
PGP-4008
Purity
≥95%
Packaging
1mg
Price
$90
Updated
2024/03/01
AK Scientific
Product number
3358CR
Product name
N-(1-Benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide
Packaging
1mg
Price
$198
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001016
Product name
PGP-4008
Purity
95.00%
Packaging
2MG
Price
$238
Updated
2021/12/16
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PGP-4008 Chemical Properties,Usage,Production

Description

PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells.

Uses

PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin[1].

References

[1] Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22. DOI:10.1021/jm0303204

PGP-4008 Preparation Products And Raw materials

Raw materials

Preparation Products

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PGP-4008 Suppliers

China 42 Switzerland 2 United Kingdom 4 United States 8 Global 56
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
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China
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9803
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58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
TargetMol Chemicals Inc.
Tel
4008200310
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marketing@tsbiochem.com
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China
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24961
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Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
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sales@szzxbio.com
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China
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2993
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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China
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9835
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ZSGB-BIO
Tel
02-400-810-9781 400810978
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sales@zsbio.com
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Sangon Biotech (Shanghai) Co.,Ltd.
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Kamiya Biomedical Company
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ordering@k-assay.com
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Cayman Chemical Company
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800-364-9897
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sales@caymanchem.com
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Enzo Biochem Inc
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Merck KGaA
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365565-02-2, PGP-4008Related Search:

2-Phenylacetamide

  • Recombinant Human p-Glycoprotein/MRP
  • PGP-4008
  • PGP-4408
  • N-(1-BENZYL-2,3-DIHYDRO-1H-PYRROLO[2,3-B]QUINOLIN-4-YL)-2-PHENYLACETAMIDE
  • Abcb1b
  • Mdr1b Rat
  • rodent multidrug resistance protein
  • Benzeneacetamide, N-[2,3-dihydro-1-(phenylmethyl)-1H-pyrrolo[2,3-b]quinolin-4-yl]-
  • PGP4008,PGP 4008
  • PGP 4008, P-glycoprotein inhibitor
  • Mdr1b Rat Vesicular Transport Kit
  • 365565-02-2
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • P-Glycoprotein
  • P to Q
  • BioChemical
  • Biochemicals and Reagents
  • proteins