ChemicalBook > CAS DataBase List > DCC-3014

DCC-3014

Product Name: DCC-3014
CAS No.: 1628606-05-2
Chemical Name: DCC-3014
Synonyms: DCC-3014;Vimseltinib;DCC-3014(Vimseltinib);Vimseltinib (DCC-3014);Vimseltinib, 10 mM in DMSO;2-(Isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one;4(3H)-Pyrimidinone, 3-methyl-2-[(1-methylethyl)amino]-5-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-;CSF1R,CD117,CSF-1 receptor,DCC 3014,SCFR,inhibit,c-Fms,DCC3014,c-Kit,CSF-1R,Vimseltinib,colony stimulating factor 1 receptor,Inhibitor
CBNumber: CB17244101
Molecular Formula: C23H25N7O2
Formula Weight: 431.49
MOL File: 1628606-05-2.mol

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DCC-3014 Property

Boiling point:: 609.2±65.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
solubility: DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 10 mg/ml
pka: 3.20±0.27(Predicted)
form: Solid
color: Off-white to light yellow
InChI: InChI=1S/C23H25N7O2/c1-14(2)27-23-25-12-18(22(31)30(23)5)19-6-7-21(15(3)28-19)32-17-8-9-24-20(10-17)16-11-26-29(4)13-16/h6-14H,1-5H3,(H,25,27)
InChIKey: TVGAHWWPABTBCX-UHFFFAOYSA-N
SMILES: C1(NC(C)C)=NC=C(C2=NC(C)=C(OC3C=CN=C(C4=CN(C)N=C4)C=3)C=C2)C(=O)N1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0121044
Product name: DCC-3014
Purity: 99.08%
Packaging: 5mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-0121044
Product name: DCC-3014
Purity: 99.08%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0121044
Product name: DCC-3014
Purity: 99.08%
Packaging: 25mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0121044
Product name: DCC-3014
Purity: 99.08%
Packaging: 50mg
Price: $2000
Updated: 2021/12/16

ChemScene

Product number: CS-0121044
Product name: DCC-3014
Purity: 99.08%
Packaging: 100mg
Price: $2950
Updated: 2021/12/16

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DCC-3014 Chemical Properties,Usage,Production

Uses

Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively[1].

References

[1] Yumi Ahn, et al. 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities. WO2014145025A2.
[2] TIMOTHY M. CALDWELL. Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)[J]. Bioorganic & Medicinal Chemistry Letters, 2022, 74: Article 128928. DOI: 10.1016/j.bmcl.2022.128928

DCC-3014 Preparation Products And Raw materials

Raw materials

Preparation Products

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1628606-05-2, DCC-3014Related Search:

DCC-3014

Vimseltinib

CSF1R,CD117,CSF-1 receptor,DCC 3014,SCFR,inhibit,c-Fms,DCC3014,c-Kit,CSF-1R,Vimseltinib,colony stimulating factor 1 receptor,Inhibitor

4(3H)-Pyrimidinone, 3-methyl-2-[(1-methylethyl)amino]-5-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-

2-(Isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one

DCC-3014(Vimseltinib)

Vimseltinib (DCC-3014)

Vimseltinib, 10 mM in DMSO

1628606-05-2